Recombinant S3Pvac-phage anticysticercosis vaccine: Simultaneous protection against cysticercosis and hydatid disease in rural pigs.

Abstract

This paper provides macroscopic and histological evidence on the statistically significant protective effects of S3Pvac-phage vaccination against porcine cysticercosis and hydatidosis. The study included 391 rustically bred pigs (187 vaccinated and 204 controls). Vaccination significantly reduced the prevalence of cysticercosis by 61.7%. Vaccination also significantly reduced by 56.1% the prevalence of hydatidosis caused by Echinococcus granulosus in pigs. The presence of the vaccine epitopes in both cestodes is probably involved in the cross-protection observed. Increased inflammation was found in 5% of cysticerci recovered from controls, versus 24% from vaccinated pigs (P<0.01). Hydatid cysts were non-inflammatory in either group. Vaccination was effective to prevent one single disease, but it failed to prevent the simultaneous infections with both parasites in a same pig. The widening of the S3Pvac-phage vaccine protective repertoire to include hydatidosis is a convenient feature that should reduce the prevalence of two frequent zoonoses that affect rustic porcine breading with a single action. Thus, the costs of two different vaccination programs would be reduced to a single one with significant reduction in both zoonoses.

• Authors: Julio Morales, Aline S de Aluja, Jose Juan Martínez, Marisela Hernández, Gabriela Rosas, Nelly Villalobos, Beatriz Hernández, Abel Blancas, Karen Manoutcharian, Goar Gevorkian, Jacquelynne Cervantes, Alicia Díaz, Agnes Fleury, Gladis Fragoso, Carlos Larralde, Edda Sciutto
• Journal: Veterinary parasitology (Vet Parasitol) Vol. 176 Issue 1 Pg. 53-8 (Feb 28 2011) ISSN: 1873-2550 [Electronic] Netherlands
• PMID: 21251758 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Helminth Proteins
• Recombinant Proteins
• Vaccines

Topics

• Animals
• Cysticercosis (prevention & control, veterinary)
• Echinococcosis (prevention & control, veterinary)
• Helminth Proteins (genetics, immunology)
• Recombinant Proteins
• Swine
• Swine Diseases (parasitology, prevention & control)
• Vaccines (immunology)