Experiments were performed on the model of chronic
heart failure. Functional capacity of myocardial structures under conditions of maximum pressure overload was within the upper limit of normal
after treatment with Adenocin. The myocardial functional reserve and potential capacity index were shown to increase to normal under these conditions.
Dobutamine,
levosimendan, and
milrinone increased functional capacity under conditions of maximum pressure overload. Treatment with adenocin restored diastolic function of the heart under conditions of maximum pressure overload. The end-diastolic pressure increased, but remained 1.7 times below the level observed in
heart failure.
After treatment with
dobutamine and
milrinone, the end-diastolic pressure (8th episode of
ligation) did not differ from the level observed in
heart failure, while after administration of
levosimendan this parameter decreased by 31%. Contraction-relaxation coupling was completely restored under the influence of Adenocin in all episodes of
ligation both before and after removal of the
ligature. Nearly all animals with
heart failure were resistant to 8 episodes of
ligation after treatment with Adenocin (89 vs. 96% under normal conditions). Under these conditions, the survival rate of animals after administration of
levosimendan,
milrinone, and
dobutamine was 65, 60, and 61%, respectively, (the mortality rate of animals with
heart failure was 75%). Adenocin, a
cardiotonic drug with cardioprotective properties, in contrast to other
cardiotonic drugs, has a modulatory effect on the system of cell energy supply, restores myocardial reserves, and improves myocardial function under conditions of overload.