Chemokines in cancer related inflammation.

Abstract

Chemokines are key players of the cancer-related inflammation. Chemokine ligands and receptors are downstream of genetic events that cause neoplastic transformation and are abundantly expressed in chronic inflammatory conditions which predispose to cancer. Components of the chemokine system affect multiple pathways of tumor progression including: leukocyte recruitment, neo-angiogenesis, tumor cell proliferation and survival, invasion and metastasis. Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.

• Authors: Paola Allavena, Giovanni Germano, Federica Marchesi, Alberto Mantovani
• Journal: Experimental cell research (Exp Cell Res) Vol. 317 Issue 5 Pg. 664-73 (Mar 10 2011) ISSN: 1090-2422 [Electronic] United States
• PMID: 21134366 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Chemical References

• Chemokines

Topics

• Animals
• Chemokines (immunology, metabolism)
• Humans
• Inflammation (etiology, immunology, metabolism)
• Neoplasms (complications, immunology, metabolism)