Antimetastatic and growth-inhibitory effects of N-acetylchitohexaose in mice bearing Lewis lung carcinoma.

Abstract

N-Acetylchitohexaose, a water-soluble oligosaccharide was found to display a significant antimetastatic effect against Lewis lung carcinoma (LLC) transplanted into C57BL/6 mice, giving rise to a 40-50% inhibition ratio of pulmonary metastasis when administered intravenously (1 mg/kg) on day 6 after the tumor implantation (5 x 10(5) cells/mouse). It was also revealed that this hexaose had a significant growth-inhibitory effect against the local tumor of the same carcinoma (a 20-30% inhibition ratio), showing an enhancing effect on concomitant immunity in local tumor-resected mice. This oligosaccharide was also shown to enhance the tumoricidal effect of splenic T lymphocytes against LLC and P-815 mastocytoma cells and to increase the natural killer activity of splenic T lymphocytes, assayed with YAC-1 cells as the target.

• Authors: K Tsukada, T Matsumoto, K Aizawa, A Tokoro, R Naruse, S Suzuki, M Suzuki
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 81 Issue 3 Pg. 259-65 (Mar 1990) ISSN: 0910-5050 [Print] Japan
• PMID: 2112529 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Oligosaccharides
• N-acetylchitohexaose

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Killer Cells, Natural (immunology)
• Lung Neoplasms (drug therapy, immunology, pathology)
• Male
• Mice
• Mice, Inbred C57BL
• Neoplasm Metastasis (prevention & control)
• Neoplasm Transplantation
• Oligosaccharides (therapeutic use)
• T-Lymphocytes, Cytotoxic (immunology)