Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats.

Abstract

The intra-plantar injection of carrageenan elicited an inflammatory response characterized by increase of the paw thickness and infiltration of neutrophils in paw tissues. Histidine, n-acetylcysteine and diclofenac decreased paw thickness, and neutrophil infiltration in the paw tissues. The anti-inflammatory effect induced by co-administration of histidine and n-acetylcysteine with diclofenac, was more than that obtained from histidine and n-acetylcysteine administered alone. The results suggested that histidine, n-acetylcysteine and diclofenac produced anti-inflammatory activities by reducing paw edema and neutrophil infiltrationin induced by carrageenan. Inhibition of cyclooxygenase products such as prostaglandins may be involved in the anti-inflammatory effects induced by histidine and n-acetylcysteine.

• Authors: Amir Abbas Farshid, Esmaeal Tamaddonfard, Fatere Yahyaee
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 48 Issue 11 Pg. 1136-42 (Nov 2010) ISSN: 0019-5189 [Print] India
• PMID: 21117455 (Publication Type: Journal Article)

Chemical References

• Cyclooxygenase Inhibitors
• Free Radical Scavengers
• Diclofenac
• Histidine
• Carrageenan
• Acetylcysteine

Topics

• Acetylcysteine (administration & dosage, pharmacology)
• Acute Disease
• Animals
• Carrageenan
• Cyclooxygenase Inhibitors (administration & dosage, pharmacology)
• Diclofenac (administration & dosage, pharmacology)
• Drug Synergism
• Edema (chemically induced, immunology, prevention & control)
• Free Radical Scavengers (administration & dosage, pharmacology)
• Hindlimb (drug effects, immunology, pathology)
• Histidine (administration & dosage, pharmacology)
• Inflammation (chemically induced, immunology, prevention & control)
• Injections (methods)
• Male
• Neutrophil Infiltration (drug effects)
• Rats
• Rats, Wistar