Plasminogen activator inhibitor 1 and visceral obesity during pronounced weight loss after bariatric surgery.

Abstract

BACKGROUND AND AIMS:

Elevated plasminogen activator inhibitor 1 (PAI-1) concentrations are a hallmark of obesity and are considered to contribute to the development of cardiovascular disease. As adipose tissue constitutes a major source for PAI-1 in obesity, we investigated the individual contribution of subcutaneous and intra-abdominal fat on PAI-1 concentrations during pronounced weight loss after bariatric surgery.

METHODS AND RESULTS:

Thirty-seven obese adults were examined before and 18 months after surgery. Abdominal fat distribution was determined by ultrasound, metabolic parameters and plasma PAI-1 levels by standard methods. BMI was reduced by 9.2 ± 4.9 kg/m(2), while total fat mass and visceral fat diameter (VFD) decreased by 20.7 ± 11.9 kg and 4.2 ± 2.3 cm, respectively. Concomitantly, PAI-1 levels diminished by 3.2 ± 5.6 ng/ml (all p ≤ 0.015). Change in PAI-1 levels was correlated with change in VFD (r = 0.441, p = 0.008), but not with subcutaneous fat diameter. In stepwise multiple regression analysis change in VFD was an independent predictor of change in PAI-1 concentrations. When adjusted for age and sex or total fat mass associations between PAI-1 and VFD remained significant.

CONCLUSION:

We demonstrate that VFD is a major determinant for PAI-1 concentrations during pronounced weight loss after bariatric surgery. Thus, significant reduction of visceral fat mass may contribute to the reduced cardiovascular morbidity and mortality after bariatric surgery by a concomitant decrease in PAI-1 concentrations.

• Authors: A Tschoner, W Sturm, J Engl, S Kaser, M Laimer, E Laimer, A Klaus, J R Patsch, C F Ebenbichler
• Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD (Nutr Metab Cardiovasc Dis) Vol. 22 Issue 4 Pg. 340-6 (Apr 2012) ISSN: 1590-3729 [Electronic] Netherlands
• PMID: 21093232 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Cholesterol, LDL
• Plasminogen Activator Inhibitor 1
• SERPINE1 protein, human

Topics

• Adult
• Bariatric Surgery
• Cholesterol, LDL (blood)
• Female
• Humans
• Linear Models
• Male
• Metabolic Syndrome (diagnosis)
• Middle Aged
• Obesity, Abdominal (blood)
• Plasminogen Activator Inhibitor 1 (blood)
• Prospective Studies
• Weight Loss