Up-regulation of the inflammatory response by ovariectomy in collagen-induced arthritis. effects of tin protoporphyrin IX.

Abstract

We have studied the influence of ovariectomy on the inflammatory response and bone metabolism on CIA as a model of postmenopausal arthritis as well as the effects of tin protoporphyrin IX (SnPP), a heme oxygenase inhibitor. Ovariectomy in non-arthritic mice produced increased serum PGD2 levels and up-regulated the expression of COX-2, h-PGDS, l-PGDS, and HO-1 in the joints. In CIA, ovariectomy potentiated the inflammatory response with higher levels of serum IL-6 and MMP-3, local PGD2 and MMP-3 as well as trabecular bone erosion. In OVX-CIA, SnPP decreased the serum levels of IL-6, MMP-3, and PGD2; down-regulated TNFα, COX-2, hPGDS, PGD2, PGE2, and MMP-3 in joint tissues; and also decreased focal bone loss in the inflamed joint. Ovariectomy up-regulates inflammatory mediators in non-arthritic and in arthritic animals. In the OVX-CIA model, SnPP exerts anti-inflammatory effects which are not associated with the prevention of systemic bone loss.

• Authors: Lidia Ibáñez, Maria José Alcaraz, Nuria Maicas, David Guede, José Ramón Caeiro, Marije I Koenders, Wim B van den Berg, Maria Luisa Ferrándiz
• Journal: Inflammation (Inflammation) Vol. 34 Issue 6 Pg. 585-96 (Dec 2011) ISSN: 1573-2576 [Electronic] United States
• PMID: 21046213 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Metalloporphyrins
• Protoporphyrins
• tin protoporphyrin IX
• Heme Oxygenase (Decyclizing)

Topics

• Animals
• Anti-Inflammatory Agents
• Arthritis, Experimental (pathology, surgery)
• Bone and Bones (metabolism)
• Heme Oxygenase (Decyclizing) (antagonists & inhibitors)
• Inflammation (etiology, genetics)
• Metalloporphyrins (pharmacology, therapeutic use)
• Mice
• Ovariectomy (adverse effects)
• Postmenopause
• Protoporphyrins (pharmacology, therapeutic use)
• Up-Regulation (physiology)