Abstract | BACKGROUND: METHODS: We genotyped the rs2296545 single-nucleotide polymorphism (Glu37Asp) in 590 Caucasian individuals and performed resting and stress echocardiography. Logistic regression was used to examine the associations of the Glu37Asp polymorphism (C allele) with cardiac hypertrophy (LV mass>100 g/m2), systolic dysfunction (LVEF<50%), diastolic dysfunction, poor treadmill exercise capacity (METS<5) and inducible ischemia. RESULTS: Compared with the 406 participants who had GG or CG genotypes, the 184 participants with the CC genotype had increased odds of left ventricular hypertrophy (OR = 1.43; 95% CI 0.99-2.06), systolic dysfunction (OR = 1.72; 95% CI 1.01-2.94), diastolic dysfunction (OR = 1.75; 95% CI 1.05-2.93), poor exercise capacity (OR = 1.61; 95% CI 1.05-2.47), and inducible ischemia (OR = 1.49, 95% CI 0.99-2.24). The Glu37Asp (CC genotype) caused a 24-fold decrease in affinity for NADH and a 2.3-fold reduction in maximal renalase enzymatic activity. CONCLUSIONS:
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Authors | Ramin Farzaneh-Far, Gary V Desir, Beeya Na, Nelson B Schiller, Mary A Whooley |
Journal | PloS one
(PLoS One)
Vol. 5
Issue 10
Pg. e13496
(Oct 20 2010)
ISSN: 1932-6203 [Electronic] United States |
PMID | 20975995
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aspartic Acid
- Glutamic Acid
- Monoamine Oxidase
- renalase
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Topics |
- Aged
- Aspartic Acid
(chemistry)
- Cardiomegaly
(genetics)
- Female
- Glutamic Acid
(chemistry)
- Humans
- Male
- Middle Aged
- Monoamine Oxidase
(chemistry, genetics)
- Myocardial Ischemia
(genetics)
- Polymorphism, Single Nucleotide
- Prospective Studies
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