Hypoadiponectinemia is strongly associated with metabolic syndrome in Korean type 2 diabetes patients.

Abstract

OBJECTIVE:

To evaluate the relationship between serum adiponectin level, dietary intake, and metabolic syndrome (MetS) in type 2 diabetes mellitus (DM) patients, and to identify factors associated with serum adiponectin level.

METHODS:

A cross-sectional study was performed using 789 type 2 DM patients (406 men and 383 women) 40-80 years old. Subjects were classified into 3 groups on the basis of serum adiponectin level. General characteristics and anthropometric, hematologic, and dietary data were obtained for each subject.

RESULTS:

The prevalence of hypoadiponectinemia (<4.0 µg/mL) was 57.4% in men and 32.4% in women. Serum adiponectin level was negatively correlated with body mass index (BMI), waist circumference, body fat percentage, and serum concentrations of insulin and triglyceride, and was positively correlated with high-density lipoprotein (HDL)-cholesterol level. Even though the direct association of nutrient intake with serum adiponectin concentration was not strong, various contributing factors for hypoadiponectinemia were strongly correlated with micronutrient intake, such as calcium, iron, and niacin. Both sexes in the group with the lowest adiponectin concentration had a higher prevalence of MetS and MetS components than corresponding sexes in the group with the highest adiponectin concentration.

CONCLUSIONS:

Our findings show that hypoadiponectinemia is strongly associated with MetS in type 2 DM patients. Dietary intake may be indirectly associated with adiponectin levels through factors such as BMI, waist circumference, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride, HDL-cholesterol, and blood pressure. Therefore, our results suggest that manipulation of the level of adiponectin may prevent MetS and reduce the risk of cardiovascular disease in type 2 DM patients.

• Authors: Han Kyoung Ryu, So Young Yu, Jong Suk Park, Young Ju Choi, Kap Bum Huh, Ji Eun Park, Ji-Yun Hwang, Wha Young Kim
• Journal: Journal of the American College of Nutrition (J Am Coll Nutr) Vol. 29 Issue 3 Pg. 171-8 (Jun 2010) ISSN: 1541-1087 [Electronic] United States
• PMID: 20833989 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adiponectin
• Cholesterol, HDL
• Insulin
• Micronutrients
• Triglycerides

Topics

• Adiponectin (blood)
• Adiposity
• Adult
• Aged
• Aged, 80 and over
• Asian People
• Body Mass Index
• Cholesterol, HDL (blood)
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (blood, complications)
• Female
• Humans
• Insulin (blood)
• Male
• Metabolic Syndrome (blood, complications)
• Micronutrients (administration & dosage)
• Middle Aged
• Sex Factors
• Triglycerides (blood)
• Waist Circumference