NFAT, immunity and cancer: a transcription factor comes of age.

Abstract

Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It is now clear that NFAT proteins have important functions in other cells of the immune system and regulate numerous developmental programmes in vertebrates. Dysregulation of these programmes can lead to malignant growth and cancer. This Review focuses on recent advances in our understanding of the transcriptional functions of NFAT proteins in the immune system and provides new insights into their potential roles in cancer development.

• Authors: Martin R Müller, Anjana Rao
• Journal: Nature reviews. Immunology (Nat Rev Immunol) Vol. 10 Issue 9 Pg. 645-56 (Sep 2010) ISSN: 1474-1741 [Electronic] England
• PMID: 20725108 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• NFATC Transcription Factors
• Transcription Factors

Topics

• Animals
• Humans
• NFATC Transcription Factors (immunology)
• Neoplasms (immunology, metabolism)
• Signal Transduction (immunology)
• T-Lymphocytes (immunology, metabolism)
• Transcription Factors (immunology)
• Transcription, Genetic