Abstract | BACKGROUND: METHODS AND RESULTS: Pooled individual data from 16 Japanese cohorts comprising 45 235 participants ages 40 to 89 years without previous history of cardiovascular disease were studied. During follow-up, 1113 incident strokes and 190 myocardial infarctions were identified. At baseline, mean ages of men and women were 55.4 and 56.5 years and mean body mass indices (BMI) were 23.0 and 23.4 kg/m(2), respectively. Compared with those with BMI <21.0, incidence rates of cerebral infarction in subjects with BMI ≥ 27.5 were significantly elevated in both men (hazard ratio, 1.81; 95% confidence interval [CI], 1.28 to 2.56) and women (hazard ratio, 1.65; 95% CI, 1.23 to 2.21), adjusted for age, smoking, and drinking habit. Incidence of cerebral hemorrhage was also associated positively with BMI in both men (hazard ratio, 2.51; 95% CI, 1.21 to 5.20) and women (hazard ratio, 1.98; 95% CI, 1.12 to 3.52). Adjustment for systolic blood pressure, a mediating factor, significantly attenuated most BMI association with stroke in both sexes. For myocardial infarction, the hazard ratio was 3.16 (95% CI, 1.66 to 6.01) for BMI 27.5 or greater versus less than 21.0 only in men, which appeared partly mediated by total cholesterol and SBP. CONCLUSIONS:
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Authors | Hiroshi Yatsuya, Hideaki Toyoshima, Kazumasa Yamagishi, Koji Tamakoshi, Masataka Taguri, Akiko Harada, Yasuo Ohashi, Yoshikuni Kita, Yoshihiko Naito, Michiko Yamada, Naohito Tanabe, Hiroyasu Iso, Hirotsugu Ueshima, Japan Arteriosclerosis Longitudinal Study (JALS) group |
Journal | Circulation. Cardiovascular quality and outcomes
(Circ Cardiovasc Qual Outcomes)
Vol. 3
Issue 5
Pg. 498-505
(Sep 2010)
ISSN: 1941-7705 [Electronic] United States |
PMID | 20699444
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Body Mass Index
- Cerebral Hemorrhage
- Female
- Follow-Up Studies
- Humans
- Incidence
- Japan
- Male
- Middle Aged
- Myocardial Infarction
(epidemiology, physiopathology)
- Obesity
(epidemiology, physiopathology)
- Risk
- Sex Factors
- Stroke
(epidemiology, physiopathology)
- Thinness
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