1. The effects of the
diterpene sclareol glycol (SG) of the
labdane family on some
dopamine (DA) related behavior (locomotor activity in mice,
apomorphine-induced stereotypy in mice and rats, and
haloperidol-induced
catalepsy in rats) were studied. 2. The locomotion frequency of mice was significantly increased by SG (stronger effect by low and medium dose). SG antagonized the hypomotility induced by
reserpine pretreatment. SG enhanced the
apomorphine decreased motility (induced by small dose of
apomorphine). 3. SG provoked increase of
apomorphine stereotypy. The long-term SG treatment augmented the sensitivity of rats to
apomorphine-induced stereotypy. 4. SG at low dose decreased
haloperidol-induced
catalepsy: at higher dose it increased the
catalepsy. SG treatment alone did not induce
catalepsy. 5. These results were discussed in the light of a possible interaction of SG with dopaminergic transmission (DA
autoreceptors and postsynaptic DA receptors) at the level of the striatum and the nucleus accumbens. The interaction of SG with
adenylate cyclase (stimulation of catalytic subunit) and with GABAergic transmission in realization of its effects on DA related behavior was also discussed.