That was then but this is now: malaria research in the time of an eradication agenda.

Abstract

The global research community must take up the challenge to work toward the eradication of malaria. In the past, malaria research has focused on drugs and vaccines that target the blood stage of infection, and mainly on the most deadly species, Plasmodium falciparum, all of which is justified by the need to prevent and treat the disease. This work remains critically important today. However, an increased research focus is now being placed on potential interventions that aim to kill the parasite stages transmitted to and by the mosquito vector because they may represent more vulnerable targets to stop the spread of malaria. Here, we highlight some of the research into malaria parasite biology that has the potential to provide new intervention targets for antimalarial drugs and vaccines.

• Authors: Stefan H I Kappe, Ashley M Vaughan, Justin A Boddey, Alan F Cowman
• Journal: Science (New York, N.Y.) (Science) Vol. 328 Issue 5980 Pg. 862-6 (May 14 2010) ISSN: 1095-9203 [Electronic] United States
• PMID: 20466924 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antimalarials
• Malaria Vaccines
• Protozoan Proteins

Topics

• Animals
• Anopheles (parasitology)
• Antimalarials (pharmacology, therapeutic use)
• Erythrocytes (parasitology)
• Humans
• Insect Vectors (parasitology)
• Life Cycle Stages
• Liver (parasitology)
• Malaria (parasitology, prevention & control)
• Malaria Vaccines (administration & dosage, immunology)
• Malaria, Falciparum (drug therapy, parasitology, prevention & control, transmission)
• Plasmodium falciparum (drug effects, growth & development, immunology, pathogenicity)
• Plastids (drug effects, metabolism)
• Protozoan Proteins (antagonists & inhibitors, metabolism)