Abstract | AIM: METHODS: RESULTS: The mean caspase 3 and 8 activity scores, oxidative stress parameters, necroinflammatory grade and prevalence of severe fibrosis were comparable across the groups with normal versus elevated ALT. Patients with nonalcoholic steatohepatitis had significantly higher caspase 3 and 8 activity (percentage of cells with positive staining per high power field), and serum malondialdehyde (mmol/l) levels than those with simple steatosis. ALT elevation was not a risk factor for advanced necroinflammatory grade and fibrosis. A receiver operating characteristic curve did not demonstrate sensitivity and specificity for discriminative power of ALT. CONCLUSION: Apoptosis and oxidative stress are the main processes contributing to disease progression in NAFLD. ALT values do not correlate with the parameters of apoptosis and oxidative stress. The disease severity can only be determined by liver biopsy.
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Authors | Billur Canbakan, Hakan Senturk, Mustafa Canbakan, Tayfur Toptas, Omur Tabak, Huriye Balci, Vakur Olgac, Gulsen Ozbay |
Journal | Biomarkers in medicine
(Biomark Med)
Vol. 4
Issue 2
Pg. 205-14
(Apr 2010)
ISSN: 1752-0363 [Print] England |
PMID | 20406065
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- NF-kappa B
- Malondialdehyde
- Superoxide Dismutase
- Alanine Transaminase
- Caspase 3
- Caspase 8
- Glutathione
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Topics |
- Adult
- Aged
- Alanine Transaminase
(blood)
- Apoptosis
- Biomarkers
(blood)
- Caspase 3
(metabolism)
- Caspase 8
(metabolism)
- Fatty Liver
(blood, pathology)
- Female
- Glutathione
(metabolism)
- Humans
- Liver
(metabolism, pathology)
- Liver Cirrhosis
(pathology)
- Male
- Malondialdehyde
(blood)
- Middle Aged
- NF-kappa B
(metabolism)
- Oxidative Stress
- Sensitivity and Specificity
- Severity of Illness Index
- Superoxide Dismutase
(metabolism)
- Young Adult
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