Abstract | BACKGROUND: METHODS: The medical records of 91 children with JIA followed between 1996 and 2006 were retrospectively reviewed for laboratory results and clinically significant adverse effects attributed to NSAID use. Laboratory abnormalities were documented, with potential adverse clinical sequelae, including if NSAID use was discontinued. RESULTS: Abnormal laboratory results were recorded for 24 of 91 patients. Nearly all abnormalities were mild and not associated with adverse clinical sequelae. All patients but one continued to receive NSAID therapy after the abnormality was detected. CONCLUSIONS: Although detection of abnormal laboratory values occurred while on NSAIDs, these abnormalities did not correlate with adverse clinical signs and symptoms. The routine monitoring of laboratory tests in asymptomatic children treated with NSAIDs is of questionable utility.
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Authors | Sheetal S Vora, Christine E Bengtson, Grant D Syverson, James J Nocton |
Journal | Pediatric rheumatology online journal
(Pediatr Rheumatol Online J)
Vol. 8
Pg. 11
(Apr 14 2010)
ISSN: 1546-0096 [Electronic] England |
PMID | 20398286
(Publication Type: Journal Article)
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