Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections.

Abstract

OBJECTIVE:

Identification of the association of killer cell immunoglobulin-like receptor (KIR) genes with SLE and accompanying infections.

METHODS:

Presence or absence of all 14 KIR genes was studied for association with SLE by case-control studies. A total of 417 SLE cases, 72 RA cases and 256 controls, all of Japanese descent, were enrolled.

RESULTS:

The carrier frequency of KIR2DL5 was significantly decreased in SLE patients compared with healthy controls [39.3 vs 50.4%; odds ratio (OR) = 0.64; 95% CI 0.36, 0.92; P = 0.005). When the prevalence of severe infections was analysed in 184 SLE patients, whose medical records were available, KIR2DL5 carriers were at an increased risk of overall infection and viral infection (crude OR = 2.66; 95% CI 1.43, 4.92; P = 0.017 and crude OR = 2.31; 95% CI 1.15, 4.62; P = 0.017, respectively). After adjusting for methylprednisolone pulse and/or cyclophosphamide pulse therapy, KIR2DL5 carriers were at significantly greater risk of infectious events overall (adjusted OR = 2.45; 95% CI 1.24, 4.81; P = 0.0095). However, KIR2DL5 carriers were marginally associated with an increased risk of viral infectious events (adjusted OR = 2.03; 95% CI 0.94, 4.41; P = 0.0718).

CONCLUSION:

KIR2DL5 was significantly associated with a decreased risk of SLE as well as an increased risk of infectious events overall in SLE patients. Our data suggest a further role of KIRs in the pathogenesis of autoimmune diseases and infection.

• Authors: Yasutaka Kimoto, Takahiko Horiuchi, Hiroshi Tsukamoto, Chikako Kiyohara, Hiroki Mitoma, Ayumi Uchino, Isao Furugo, Seiji Yoshizawa, Akira Ueda, Shinichi Harashima, Takuya Sawabe, Tomoko Tahira, Kenshi Hayashi, Shigeru Yoshizawa, Terufumi Shimoda, Koichi Akashi, Mine Harada
• Journal: Rheumatology (Oxford, England) (Rheumatology (Oxford)) Vol. 49 Issue 7 Pg. 1346-53 (Jul 2010) ISSN: 1462-0332 [Electronic] England
• PMID: 20371502 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, KIR2DL5

Topics

• Asian People (genetics)
• Case-Control Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Lupus Erythematosus, Systemic (genetics, immunology)
• Polymorphism, Genetic
• Receptors, KIR2DL5 (genetics, immunology)
• Regression Analysis