Abstract | IMPORTANCE OF THE FIELD:
Cannabinoids have been proposed as clinically promising neuroprotective molecules, based on their capability to normalize glutamate homeostasis, reducing excitotoxicity, to inhibit calcium influx, lowering intracellular levels and the subsequent activation of calcium-dependent destructive pathways, and to reduce the generation of reactive oxygen intermediates or to limit their toxicity, decreasing oxidative injury. Cannabinoids are also able to decrease local inflammatory events by acting on glial processes that regulate neuronal survival, and to restore blood supply by reducing vasocontriction produced by several endothelium-derived factors. AREAS COVERED IN THIS REVIEW: WHAT THE READER WILL GAIN: Most of the information reviewed here relates to preclinical studies. However, these molecules may progress from the present preclinical evidence to clinical applications. TAKE HOME MESSAGE:
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Authors | Javier Fernández-Ruiz, Concepción García, Onintza Sagredo, María Gómez-Ruiz, Eva de Lago |
Journal | Expert opinion on therapeutic targets
(Expert Opin Ther Targets)
Vol. 14
Issue 4
Pg. 387-404
(Apr 2010)
ISSN: 1744-7631 [Electronic] England |
PMID | 20230193
(Publication Type: Journal Article, Review)
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Chemical References |
- Cannabinoid Receptor Modulators
- Endocannabinoids
- Neuroprotective Agents
- Receptors, Cannabinoid
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Topics |
- Animals
- Cannabinoid Receptor Modulators
(physiology)
- Cell Death
(physiology)
- Cell Survival
(physiology)
- Endocannabinoids
- Humans
- Nervous System Diseases
(drug therapy)
- Neuroprotective Agents
(pharmacology, therapeutic use)
- Receptors, Cannabinoid
(drug effects)
- Signal Transduction
(drug effects, physiology)
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