Glutamate receptor biology and its clinical significance in neuropsychiatric systemic lupus erythematosus.

Abstract

The recent appreciation that a subset of anti-DNA antibodies cross-reacts with the N-methyl-d-aspartate receptor encourages a renewed examination of antibrain reactivity in systemic lupus erythematosus (SLE) autoantibodies. Moreover, investigations of their autospecificity present a paradigm for studies of antibrain reactivity and show that (1) serum antibodies access brain tissue only after a compromise of blood-brain barrier integrity, (2) the same antibodies have differential effects on brain function depending on the region of brain exposed to the antibodies, and (3) insults to the blood-brain barrier are regional rather than diffuse. These studies suggest that an anatomic classification scheme for neuropsychiatric SLE may facilitate research on etiopathogenesis and the design of clinical trials.

• Authors: Cynthia Aranow, Betty Diamond, Meggan Mackay
• Journal: Rheumatic diseases clinics of North America (Rheum Dis Clin North Am) Vol. 36 Issue 1 Pg. 187-201, x-xi (Feb 2010) ISSN: 1558-3163 [Electronic] United States
• PMID: 20202599 (Publication Type: Journal Article)
• Copyright: Copyright 2010 Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Antinuclear
• Receptors, N-Methyl-D-Aspartate

Topics

• Animals
• Antibodies, Antinuclear (immunology)
• Blood-Brain Barrier
• Humans
• Lupus Vasculitis, Central Nervous System (immunology, psychology)
• Mice
• Receptors, N-Methyl-D-Aspartate (immunology)