Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage.
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| Abstract |
An alcoholic fatty liver disease was induced by drinking water containing 20% (w/w) alcohol. Therapeutic groups were orally administrated dosages of 0.25 g silymarin/kg body weight (BW) and a low dosage of Niuchangchih (Antrodia camphorata) (0.025 g/kg BW) and a high dosage of Niuchangchih (0.1 g/kg BW) per day. Niuchangchih, especially at the high dosage, not only showed a hypercholesterolemic effect (p < 0.05) but also reduced (p < 0.05) hepatic lipids in alcohol-fed rats. Those beneficial effects could be partially attributed to higher (p < 0.05) fecal cholesterol and bile acid outputs, as well as downregulations (p < 0.05) of 3-hydroxy-3-methylglutaryl-CoA reductase, sterol regulatory element-binding protein-1c, acetyl-CoA carboxylase, fatty acid synthase, and malic enzyme gene expressions; meanwhile, there was an upregulation of low-density lipoprotein receptor and peroxisome proliferator-activated alpha gene expression. Besides, Niuchangchih also enhanced (p < 0.05) the liver glutathione, Trolox equivalent antioxidant capacity, and activities of superoxide dismutase, catalase, and glutathione peroxidase and decreased the liver malondialdehyde content, which also partially contributed to the lowered (p < 0.05) serum aspartate aminotransferase levels and no observed lesion in the histological examination of alcohol-fed rats.
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| Authors | Chia-Hsin Huang, Yuan-Yen Chang, Cheng-Wei Liu, Wen-Yu Kang, Yi-Ling Lin, Hsien-Chang Chang, Yi-Chen Chen |
| Journal | Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 58 Issue 6 Pg. 3859-66 (Mar 24 2010) ISSN: 1520-5118 [Electronic] United States |
| PMID | 20192205 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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