LDL Receptors (LDL Receptor)

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1897 relevant articles (60 outcomes, 199 trials/studies) found for this Bio-Agent

Description: Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.

Also Known As:

LDL Receptor; Low Density Lipoprotein Receptor; Receptors, LDL; LDL Receptors, Lipoprotein; Low Density Lipoprotein Receptors; Receptors, Lipoprotein, LDL; Receptor, LDL; Receptors, Lipoprotein LDL; Lipoprotein LDL Receptors; Receptors, Low Density Lipoprotein

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Bio-Agent Context: Research Results

Experts

1.	Harats, D: 8 articles (10/2001 - 01/2000)
2.	Shaish, A: 6 articles (10/2001 - 01/2000)
3.	George, J: 6 articles (10/2001 - 03/2000)
4.	Maeda, Nobuyo: 5 articles (10/2008 - 08/2004)
5.	Fazio, Sergio: 5 articles (09/2007 - 11/2002)
6.	Linton, MacRae F: 5 articles (09/2007 - 11/2002)
7.	Libby, Peter: 5 articles (04/2007 - 09/2002)
8.	Afek, A: 5 articles (10/2001 - 03/2000)
9.	Levkovitz, H: 5 articles (10/2001 - 01/2000)
10.	Harats, Dror: 4 articles (10/2008 - 01/2003)

Related Diseases

1.	Atherosclerosis (Atheroma) 04/30/2007 - "These results show for the first time that this dual Tx inhibitor is effective in reducing atherogenesis in the LDL receptor deficient mice. " 03/01/2001 - "Identification of the gene in this region may lead to new insights into the mechanisms of LDL receptor-mediated uptake of LDL by cells and may help to identify further genetic risk factors for premature atherosclerosis." 10/01/2009 - "CONCLUSION: This study surprisingly revealed that atherogenesis does not require CD44 expression on hematopoietic cells in the LDL receptor-deficient mouse model. " 04/01/2009 - "In this study we observed the effect of CRH on atherosclerosis in low-density lipoprotein receptor-deficient (LDLr-/-) mice. " 11/01/2008 - "For atherosclerosis studies, mice were crossed onto the LDL-receptor deficient background. " Order ALL the reference details at left...
2.	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 03/01/2007 - "BACKGROUND: Phenocopies of homozygous familial hypercholesterolemia (hoFH) having autosomal recessive inheritance, were recently found to arise from defects in the LDL receptor (LDLR) adapter protein, called ARH, which facilitates the clearance of circulating LDL. " 12/01/2002 - "Familial hypercholesterolemia is an autosomal dominant disorder with a gene-dosage effect that is usually caused by mutations in the LDL receptor gene that disrupt normal clearance of LDL. " 11/01/1998 - "In view of the presence of some 190 mutations in the low density lipoprotein receptor (LDL-R) gene and a lack of simple detection methods, we have developed an improved assay system for detecting familial hypercholesterolemia (FH) using mitogen-induced proliferating lymphocytes. " 11/01/1998 - "Improved detection of familial hypercholesterolemia by determining low density lipoprotein receptor expression in mitogen-induced proliferating lymphocytes." 02/01/2009 - "BACKGROUND: The objective of this study was to develop a new and simple method for measuring low-density lipoprotein receptor (LDLR) activity using peripheral lymphocytes enabling us to clinically diagnose familial hypercholesterolemia (FH) and ascertain the involved mutations (such as K790X mutation), that might not be clearly detected in the conventional method. " Order ALL the reference details at left...
3.	Hypercholesterolemia 01/01/2006 - "Upregulation of liver LDL receptor expression is effective in treating hypercholesterolemia. " 01/01/2009 - "This study utilized a mouse model of hypercholesterolemia, low-density lipoprotein receptor knockout (LDLr(-/-)) mice fed a high-fat diet for 5 months, to test the hypothesis that farnesoid X receptor (FXR) deficiency contributed to NASH development. " 08/01/2008 - "OBJECTIVE: The objective of this study was to examine the role of maternal hypercholesterolemia in fetal programming of adult vascular function using transgenic mice lacking the low-density lipoprotein receptor (LDLR). " 11/23/2007 - "In this study we examined the effect of hypercholesterolemia on cuff-induced intimal thickening in LDL-receptor knockout (LDLR-/-) mice fed with a high-fat diet. " 12/01/2001 - "In this study, 46 Thai patients with primary hypercholesterolemia were screened for mutations in exon 9 of the LDL receptor gene by polymerase chain reaction-restriction fragment length polymorphism (PCR - RFLP). " Order ALL the reference details at left...
4.	Hyperlipidemias (Hyperlipidemia) 10/01/2003 - "Molecular analysis of the LDL receptor gene will clearly identify the cause of the patient's hyperlipidemia and allow appropriate early treatment as well as antenatal and family studies." 10/05/2001 - "In the current study, we show an unexpectedly severe hyperlipidemia in ob/ob mice on a background of low density lipoprotein receptor (LDLR) deficiency (-/-). " 02/01/2009 - "Some OM effects are clinically desirable such as reducing hyperlipidemia through the activation of hepatic LDL receptor transcription, a downstream event of ERK activation. " 07/07/2006 - "LDL receptor-deficient (LDLR(-/-)) mice exhibit mild hyperlipidemia on a chow diet but develop severe hyperlipidemia on a high fat diet. " 07/07/2006 - "Hyperlipidemia is a major determinant of neointimal formation in LDL receptor-deficient mice." Order ALL the reference details at left...
5.	Coronary Disease (Coronary Heart Disease) 12/01/2008 - "PCSK9 gain of function mutations cause hypercholesterolaemia by a reduction of LDL receptor levels, while PCSK9 loss of function variants are associated with a reduction of LDL-C values and a decreased risk of coronary heart disease. " 01/01/1999 - "Effects of Ava II and Hinc II polymorphisms at the LDL receptor gene on serum lipid levels of Brazilian individuals with high risk for coronary heart disease." 01/01/1998 - "We conclude that only part of the variable phenotype of heterozygous FH patients is explained by different LDL-receptor defects and that other factors determine the severity of their hypercholesterolaemia and the onset of coronary disease." 05/01/1997 - "Comparison of the effect of two low-density lipoprotein receptor class mutations on coronary heart disease among French-Canadian patients heterozygous for familial hypercholesterolaemia." 03/01/2009 - "Low density lipoprotein receptor polymorphisms and the risk of coronary heart disease: the Atherosclerosis Risk in Communities Study." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Lipoproteins (Lipoprotein)
2.	Cholesterol
3.	Apolipoproteins
4.	Apolipoprotein A-I (Apolipoprotein A1)
5.	Chylomicron Remnants
6.	Apolipoproteins E (ApoE)
7.	Apolipoproteins B (ApoB)
8.	Lipoprotein Lipase (Diacylglycerol Lipase)
9.	Estrogens (Estrogen)
10.	LDL Lipoproteins (beta Lipoproteins)

Related Therapies and Procedures

1.	Blood Component Removal (Apheresis)
2.	Transplantation (Transplant Recipients)
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Lasers (Laser)
5.	Photochemotherapy (Photodynamic Therapy)

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