mRNA expression of the XAGE-1 gene in human acute leukemia.

Abstract

XAGE-1 is a cancer-testis antigen, which was demonstrated to be expressed at a significant frequency and to be immunogenic in some solid tumors. We analyzed the expression of 4 XAGE-1 transcript variant gene in human acute leukemias by reverse-transcription polymerase chain reaction. Among the 114 acute leukemias, 14/63 (22.22%) of the acute myeloid leukemia samples were positive for XAGE-1b genes. XAGE-1b mRNA expression was detected in 10/51 (19.61%) of the acute lymphocyte leukemia samples. However, we did not find any important correlation between XAGE-1b mRNA expression and clinical characteristics, such as sex, leukemia type, response to therapy and the percentage of blast in the first diagnosed bone marrow. We concluded that the XAGE-1b gene was expressed at the mRNA level in a proportion of human acute leukemia.

• Authors: Yuqiang Ji, Wanggang Zhang, Jin Wang, Liufang Gu
• Journal: International journal of hematology (Int J Hematol) Vol. 91 Issue 2 Pg. 209-12 (Mar 2010) ISSN: 1865-3774 [Electronic] Japan
• PMID: 20178013 (Publication Type: Journal Article)

Chemical References

• Antigens, Neoplasm
• RNA, Messenger
• XAGE1A protein, human

Topics

• Adolescent
• Adult
• Aged
• Antigens, Neoplasm (genetics)
• Bone Marrow (physiology)
• Female
• Gene Expression Regulation, Leukemic
• Humans
• Leukemia, Myeloid, Acute (genetics)
• Male
• Middle Aged
• Phenotype
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics)
• RNA, Messenger (metabolism)
• Reverse Transcriptase Polymerase Chain Reaction
• Young Adult