Abstract | OBJECTIVES: METHODS: We included 158 incident cases of colorectal cancer and 563 randomly chosen control subjects from 28,345 women in the Women's Health Study aged 45 or older who provided blood samples and had no history of cancer or cardiovascular disease at baseline in 1993. All cases and controls were Caucasians of European descent. A total of 63 tagging and putative functional SNPs in the 5 genes were included for analysis. Unconditional logistic regression was used to estimate odds ratio ( ORs) and 95% confidence intervals (CIs). RESULTS: There was no association between variation in ESR1, ESR2, PGR, CYP19A1 and HSD17B2 and colorectal cancer risk after correction for multiple comparisons (p values after correction > or =0.25). There was also no association with any of the haplotypes examined (p > or = 0.15) and no evidence of joint effects of variants in the 5 genes (p > or = 0.51). CONCLUSION: Our data offer insufficient support for an association between variation in ESR1, ESR2, PGR, CYP19A1, and HSD17B2 and risk for developing colorectal cancer.
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Authors | Jennifer Lin, Robert Y L Zee, Kuang-Yu Liu, Shumin M Zhang, I-Min Lee, JoAnn E Manson, Edward Giovannucci, Julie E Buring, Nancy R Cook |
Journal | Cancer causes & control : CCC
(Cancer Causes Control)
Vol. 21
Issue 6
Pg. 897-908
(Jun 2010)
ISSN: 1573-7225 [Electronic] Netherlands |
PMID | 20148360
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Gonadal Steroid Hormones
- Receptors, Estrogen
- Receptors, Progesterone
- Receptors, Steroid
- Estradiol Dehydrogenases
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Topics |
- Aged
- Colorectal Neoplasms
(genetics)
- Estradiol Dehydrogenases
(genetics)
- Ethnicity
(genetics)
- Female
- Genetic Variation
(genetics)
- Gonadal Steroid Hormones
(genetics)
- Haplotypes
- Humans
- Logistic Models
- Middle Aged
- Odds Ratio
- Polymorphism, Single Nucleotide
- Receptors, Estrogen
(genetics)
- Receptors, Progesterone
(genetics)
- Receptors, Steroid
(genetics)
- Risk Factors
- White People
(genetics)
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