HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Aromatase (CYP19)

An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Also Known As:
CYP19; Androstenedione Aromatase; CYP 19; CYP19 Protein; Cytochrome P450 19; Estrogen Synthase; Estrogen Synthetase; P450AROM; Aromatase, Androstenedione; Cytochrome P 450 CYP19; Protein, CYP19; Cytochrome P-450 CYP19; Cytochrome P-450(AROM)
Networked: 2849 relevant articles (107 outcomes, 505 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Sasano, Hironobu: 63 articles (04/2021 - 01/2002)
2. Chen, Shiuan: 49 articles (01/2021 - 04/2002)
3. Simpson, Evan R: 48 articles (12/2016 - 01/2002)
4. Suzuki, Takashi: 44 articles (10/2017 - 01/2002)
5. Miki, Yasuhiro: 42 articles (02/2018 - 01/2005)
6. Bulun, Serdar E: 41 articles (01/2022 - 03/2002)
7. Brown, Kristy A: 25 articles (01/2021 - 07/2009)
8. Brueggemeier, Robert W: 25 articles (02/2012 - 02/2002)
9. Dannenberg, Andrew J: 23 articles (01/2022 - 05/2006)
10. Clyne, Colin D: 22 articles (01/2015 - 06/2002)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Neoplasms (Cancer)
3. Endometriosis
4. Leiomyoma (Uterine Fibroids)
5. Obesity

Related Drugs and Biologics

1. Aromatase Inhibitors
2. Enzymes
3. Hormones (Hormone)
4. Estrogens (Estrogen)
5. Aromatase (CYP19)
6. Letrozole (Femara)
7. Estrogen Receptors
8. exemestane (Aromasin)
9. Anastrozole (Arimidex)
10. Steryl-Sulfatase (Steroid Sulfatase)

Related Therapies and Procedures

1. Therapeutics
2. Radiotherapy
3. Chemoprevention
4. Lasers (Laser)
5. Drug Therapy (Chemotherapy)