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Hydroxysteroid Dehydrogenases

Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzyme Nomenclature, 1992) EC 1.1.-.
Also Known As:
Dehydrogenase, Hydroxysteroid; Dehydrogenases, Hydroxysteroid; Hydroxysteroid Dehydrogenase
Networked: 313 relevant articles (7 outcomes, 31 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Sasano, Hironobu: 6 articles (06/2022 - 04/2005)
2. Penning, Trevor M: 6 articles (01/2019 - 03/2006)
3. Pasqualini, Jorge R: 4 articles (04/2009 - 02/2003)
4. Belyaeva, Olga V: 3 articles (01/2021 - 01/2019)
5. Brown, Philip M: 3 articles (01/2021 - 01/2019)
6. Kedishvili, Natalia Y: 3 articles (01/2021 - 01/2019)
7. Ma, Yanling: 3 articles (01/2021 - 01/2019)
8. Rotman, Yaron: 3 articles (01/2021 - 01/2019)
9. Miki, Yasuhiro: 3 articles (01/2020 - 12/2005)
10. Byrns, Michael C: 3 articles (03/2013 - 05/2011)

Related Diseases

1. Body Weight (Weight, Body)
01/01/1986 - "I. Measurement of body weight, ovarian weight and histochemical activity of 17 beta-hydroxysteroid dehydrogenase."
01/01/2003 - "In utero exposure to supranormal levels (10 mg/kg body weight or 25 mg/kg body weight) of hydroxyprogesterone decreased the activity levels of marker steroidogenic enzymes (3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase) of adult (mature) rat testis. "
01/01/1986 - "The effects of administration of 1.25 mg testosterone propionate between the 2nd and 5th day of life on body weight, ovarian weight, food and water consumption, and the histochemical activity of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) were studied in female Wistar rats during the evolution of experimental micropolycystic ovaries. "
12/01/1999 - "Significant reduction of testicular and accessory sex organs (seminal vesicle, ventral prostate) weight, along with inhibition of testicular delta 5-3 beta-hydroxysteroid dehydrogenase (delta 5-3 beta-HSD) and 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activity and reduction in plasma testosterone level, were observed at the doses of 2000 and 3000 micrograms/kg body weight/day. "
01/01/2002 - "No changes were evident in the body weight, testicular, epididymal and accessory organ weight at all the dose levels tested, although a decline in sperm count and sperm motility along with an increase in abnormal sperm was noticed at 900 ppm. The activity of marker testicular enzymes, mainly 17-beta hydroxysteroid dehydrogenase (17-betaHSD) and gamma glutamyl transpeptidase (gamma-GT), associated with specific cell types were altered. "
2. Prostatic Neoplasms (Prostate Cancer)
3. Type 2 Diabetes Mellitus (MODY)
4. Neoplasms (Cancer)
5. Insulin Resistance

Related Drugs and Biologics

1. Testosterone (Sustanon)
2. 3-Hydroxysteroid Dehydrogenases (3 beta Hydroxysteroid Dehydrogenase)
3. Proteins (Proteins, Gene)
4. Hormones (Hormone)
5. Estradiol (Delestrogen)
6. Steroids
7. Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)
8. Androgen Receptors (Androgen Receptor)
9. Gonadal Steroid Hormones (Sex Hormones)
10. DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1. Castration
2. Therapeutics
3. Orchiopexy