Chemoattractants and receptors in Alzheimer's disease.

Abstract

Chemoattractants, including classical chemoattractants and chemokines, are mediators of leukocyte trafficking in physiological immunosurveillance as well as recruitment of leukocyte to the sites of inflammation and injury. Besides their well-established role in the immune system, recent researches have demonstrated that chemoattractants and their receptors are also involved in brain development and in the maintenance of normal brain homeostasis. Evidence is emerging that chemoattractants and their receptors play important roles in neuroinflammation, neuronal death and hence neurodegenerative diseases. In this review, we summarize recent progress regarding the involvement of chemoattractants and their receptors in Alzheimer's disease and their potential as therapeutic targets.

• Authors: Lingfei Ruan, Yan Kong, Ji Ming Wang, Yingying Le
• Journal: Frontiers in bioscience (Scholar edition) (Front Biosci (Schol Ed)) Vol. 2 Issue 2 Pg. 504-14 (01 01 2010) ISSN: 1945-0524 [Electronic] Singapore
• PMID: 20036964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Chemokines
• Chemotactic Factors
• Receptors, Chemokine
• Receptors, Formyl Peptide

Topics

• Alzheimer Disease (immunology, metabolism)
• Brain (growth & development, metabolism, physiopathology)
• Chemokines (metabolism)
• Chemotactic Factors (metabolism)
• Humans
• Receptors, Chemokine (metabolism)
• Receptors, Formyl Peptide (metabolism)