[Neuroprotective effects of dibornol and mechanism of its action in rats with cerebral ischemia].

Abstract

Neuroprotective activity of the new sterically hindered phenolic antioxidant 4-methyl-2,6-diisobornylphenol (dibornol) in rats with total transient cerebral ischemia was investigated. Dibornol decreased mortality of rats and the number of animals with severe neurological deficit; moreover, it accelerated restoration of neurological status in the survived rats. Neuroprotective activity of dibornol is based on its ability to diminish lipid peroxidation in ischemic brain, suppress cerebral tissue hypoxia and protect functional activity of endothelium. Improved oxygen delivery was a consequence of reduced hyperviscosity syndrome (enhanced deformability of erythrocytes and their decreased aggregation).

• Authors: M B Plotnikov, G A Chernysheva, V I Smol'iakova, I S Ivanov, A V Kuchin, I Iu Chukicheva, E A Krasnov
• Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 11 Pg. 12-7 ( 2009) ISSN: 0869-6047 [Print] Russia (Federation)
• PMID: 20017401 (Publication Type: Comparative Study, Journal Article)

Chemical References

• 4-methyl-2,6-diisobornylphenol
• Camphanes
• Cresols
• Neuroprotective Agents

Topics

• Administration, Oral
• Animals
• Brain Ischemia (drug therapy, metabolism)
• Camphanes (administration & dosage, therapeutic use)
• Cresols (administration & dosage, therapeutic use)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Female
• Lipid Peroxidation (drug effects)
• Male
• Neuroprotective Agents (administration & dosage, therapeutic use)
• Oxygen Consumption (drug effects, physiology)
• Rats
• Rats, Wistar
• Treatment Outcome