Leptin and the clinical cardiovascular risk.

Abstract

Obesity is a universal health problem of increasing prevalence and represents a major public health concern. Obesity is associated with a high risk of developing cardiovascular and metabolic diseases such as hypertension, coronary atherosclerosis, myocardial hypertrophy, diabetes, dyslipidemia, and increased cardiovascular morbidity and mortality. There has been an ongoing search for mediators between obesity and cardiovascular disease. Leptin is a novel and very promising molecule of research that may link these pathologic conditions. Since its discovery in 1994, major advances have been made in the understanding of neuroendocrine mechanisms regulating appetite, metabolism, adiposity, sympathetic tone and blood pressure. In this review, we discuss the physiological and pathophysiological roles of leptin in the causation of various cardiovascular diseases.

• Authors: Mukesh Singh, Updesh S Bedi, Param P Singh, Rohit Arora, Sandeep Khosla
• Journal: International journal of cardiology (Int J Cardiol) Vol. 140 Issue 3 Pg. 266-71 (Apr 30 2010) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 19944469 (Publication Type: Journal Article, Review)
• Copyright: Copyright (c) 2009. Published by Elsevier Ireland Ltd.

Chemical References

• Leptin

Topics

• Cardiovascular Diseases (metabolism, physiopathology)
• Diabetes Mellitus (metabolism)
• Homeostasis (physiology)
• Humans
• Hypertension (metabolism)
• Leptin (metabolism)
• Obesity (metabolism)
• Risk Factors