HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Acute cardiac dysfunction after short-term diesel exhaust particles exposure.

Abstract
Epidemiological studies show an association between particulate matter exposure and acute heart failure. However, underlying mechanisms remain unclear. In this study, we investigated acute cardiac hemodynamic effects and related mechanisms after 1 day exposure to diesel exhaust particles (DEPs). Male Sprague-Dawley rats were randomized and instilled with 250 microg (low dose) or 500 microg (high dose) of DEP or saline placebo intra-tracheally. The cardiac systolic function by dP/dt(40) and diastolic functions by maximal negative dP/dt were both worse in DEP low dose and DEP high dose groups than the control group, respectively. In the heart rate variability analysis, SDNN in DEP low dose and DEP high dose groups were both lower than the control group. The low frequency heart rate variability was higher in the DEP groups compared to the control group. The cardiac IL-1beta expression and circulating cardiac troponin I level were higher in the DEP group than the control group. Plasma IL-1beta and IL-6 protein were significantly higher in the DEP groups than the control group. In conclusion, DEP exposure causes acute cardiac systolic and diastolic dysfunction. The changes may be related to decreased heart rate variability, increased cardiac inflammatory reaction and myocardial damage.
AuthorsChien-Hua Huang, Lian-Yu Lin, Min-Shan Tsai, Chiung-Yuan Hsu, Huei-Wen Chen, Tzung-Dau Wang, Wei-Tien Chang, Tsun-Jen Cheng, Wen-Jone Chen
JournalToxicology letters (Toxicol Lett) Vol. 192 Issue 3 Pg. 349-55 (Feb 15 2010) ISSN: 1879-3169 [Electronic] Netherlands
PMID19913602 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2009 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Interleukin-1beta
  • Interleukin-6
  • Particulate Matter
  • Troponin I
  • Vehicle Emissions
Topics
  • Administration, Inhalation
  • Animals
  • Blood Pressure (drug effects)
  • Dose-Response Relationship, Drug
  • Electrocardiography (drug effects)
  • Heart (drug effects)
  • Heart Rate (drug effects)
  • Interleukin-1beta (blood)
  • Interleukin-6 (blood)
  • Male
  • Particulate Matter (toxicity)
  • Rats
  • Rats, Sprague-Dawley
  • Troponin I (blood)
  • Vehicle Emissions (toxicity)
  • Ventricular Dysfunction (chemically induced)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: