Abstract | BACKGROUND AND PURPOSE:
Antidepressants are a first-line treatment against neuropathic pain. We previously demonstrated that beta(2)-adrenoceptors are necessary for antidepressants to exert their anti-allodynic action. The aim of the present study was to assess whether beta(2)-adrenoceptor agonists could be sufficient to alleviate neuropathic allodynia. EXPERIMENTAL APPROACH: We used a murine model of neuropathy induced by unilateral sciatic nerve cuffing in C57BL/6J mice. We previously demonstrated that this animal model is sensitive to chronic, but not to acute, treatment with antidepressant drugs, which is clinically relevant. The mechanical allodynia was evaluated using the von Frey filaments. KEY RESULTS: CONCLUSIONS AND IMPLICATIONS: Our data show that chronic treatment with beta- adrenoceptor agonists has the same antiallodynic properties as treatments with antidepressant drugs. This study was, however, conducted in an animal model, and a clinical validation will be required to confirm the value of the present findings in patients.
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Authors | Nada Choucair-Jaafar, Ipek Yalcin, Jean-Luc Rodeau, Elisabeth Waltisperger, Marie-José Freund-Mercier, Michel Barrot |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 158
Issue 7
Pg. 1683-94
(Dec 2009)
ISSN: 1476-5381 [Electronic] England |
PMID | 19912227
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-2 Receptor Agonists
- Adrenergic beta-Agonists
- Adrenergic beta-Antagonists
- Propanolamines
- ICI 118551
- Propranolol
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Topics |
- Adrenergic beta-2 Receptor Agonists
- Adrenergic beta-Agonists
(administration & dosage, pharmacology)
- Adrenergic beta-Antagonists
(administration & dosage, pharmacology)
- Animals
- Disease Models, Animal
- Drug Administration Schedule
- Male
- Mice
- Mice, Inbred C57BL
- Neuralgia
(drug therapy)
- Pain Measurement
- Propanolamines
(administration & dosage, pharmacology)
- Propranolol
(administration & dosage, pharmacology)
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