Abstract | BACKGROUND: Depot antipsychotics are widely used in clinical practice. Long-acting formulations of second-generation antipsychotics are now being developed and introduced. AIMS: To review the pharmacology, pharmacokinetics and adverse effect profiles of currently available antipsychotic long-acting injections (LAIs). METHOD: The psychopharmacological properties of first- and second-generation antipsychotic LAIs are reviewed using data available up to October 2008. RESULTS: CONCLUSIONS: Dosing of LAIs is complicated by delayed release of drug, changes in plasma levels without change in dose, and by the lack of data establishing clear dose requirements. All LAIs offer the prospect of assured adherence (although patients may still default on treatment) but their use is complicated by adverse effects, complex pharmacokinetics and confusion over dose-response relationships.
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Authors | David Taylor |
Journal | The British journal of psychiatry. Supplement
(Br J Psychiatry Suppl)
Vol. 52
Pg. S13-9
(Nov 2009)
ISSN: 0960-5371 [Print] England |
PMID | 19880912
(Publication Type: Journal Article, Review)
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Chemical References |
- Antipsychotic Agents
- Delayed-Action Preparations
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Topics |
- Antipsychotic Agents
(pharmacology, therapeutic use)
- Delayed-Action Preparations
(pharmacology, therapeutic use)
- Drug Administration Schedule
- Drug-Related Side Effects and Adverse Reactions
- Dyskinesia, Drug-Induced
(etiology)
- Humans
- Medication Adherence
- Psychotic Disorders
(drug therapy)
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