Metachronous bilateral testicular germ cell tumors: report of two cases.

Abstract

Metachronous bilateral testicular germ cell tumors is a rare known problem. However, no report of metachronus bilateralism was identified in the PubMed database published from India so far, where testicular cancer is relatively rare. We report the cases of two gentlemen. One had stage 1 nonseminomatous germ cell tumor (NSGCT) at the age of 32 in 1990 and developed marker relapse on surveillance and had chemotherapy using cisplatin and etoposide for four cycles. He developed contralateral seminoma in the testis 13 years later. Another patient had left orchidectomy in 2003 for NSGCT, had adjuvant BEP for two cycles, and developed a contralateral testicular tumor 5 years later, which was also seminoma. As more patients with germ cell tumors are cured with chemotherapy, long-term problems become important. Contralateral testicular tumor is one of them. As it can be very late, many years of continued follow-up examination and patients' awareness are necessary.

• Authors: Francis V James, Aswin Kumar, P G Jayaprakash, Anitha Mathews
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) 2009 Jul-Sep Vol. 5 Issue 3 Pg. 206-7 ISSN: 1998-4138 [Electronic] India
• PMID: 19841564 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Antineoplastic Agents, Phytogenic
• Etoposide
• Cisplatin

Topics

• Adult
• Antineoplastic Agents (therapeutic use)
• Antineoplastic Agents, Phytogenic (therapeutic use)
• Cisplatin (therapeutic use)
• Etoposide (therapeutic use)
• Follow-Up Studies
• Humans
• India
• Male
• Neoplasm Staging
• Neoplasms, Germ Cell and Embryonal (drug therapy, pathology, surgery)
• Orchiectomy
• Seminoma (drug therapy, pathology, surgery)
• Testicular Neoplasms (drug therapy, pathology, surgery)
• Time Factors
• Young Adult