Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: We used three types of genetically engineered mice: brain NP (BNP) transgenic (BNP-Tg), cGK-Tg, and guanylyl cyclase-A (GCA) heterozygous knockout (GCA(+/-)) mice and analyzed the metabolic consequences of chronic activation of NP/cGK cascades in vivo. We also examined the effect of NPs in cultured myocytes. RESULTS: CONCLUSIONS: The findings together suggest that NP/cGK cascades can promote muscle mitochondrial biogenesis and fat oxidation, as to prevent obesity and glucose intolerance. The vascular hormone, NP, would contribute to coordinated regulation of oxygen supply and consumption.
|
Authors | Kazutoshi Miyashita, Hiroshi Itoh, Hirokazu Tsujimoto, Naohisa Tamura, Yasutomo Fukunaga, Masakatsu Sone, Kenichi Yamahara, Daisuke Taura, Megumi Inuzuka, Takuhiro Sonoyama, Kazuwa Nakao |
Journal | Diabetes
(Diabetes)
Vol. 58
Issue 12
Pg. 2880-92
(Dec 2009)
ISSN: 1939-327X [Electronic] United States |
PMID | 19690065
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Blood Glucose
- Dietary Fats
- Natriuretic Peptides
- PPAR delta
- PPAR gamma
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Ppargc1a protein, mouse
- Trans-Activators
- Transcription Factors
- Natriuretic Peptide, Brain
- Protein Kinases
- Receptors, Atrial Natriuretic Factor
- atrial natriuretic factor receptor A
- Cyclic GMP
|
Topics |
- Animals
- Blood Glucose
(metabolism)
- Cells, Cultured
- Cyclic GMP
(metabolism)
- Dietary Fats
(administration & dosage, adverse effects, metabolism)
- Down-Regulation
- Genetic Engineering
- Glucose Intolerance
(etiology, metabolism)
- Insulin Resistance
- Lipid Peroxidation
- Mice
- Mice, Knockout
- Mitochondria
(metabolism)
- Molecular Sequence Data
- Muscle Cells
(metabolism)
- Muscle, Skeletal
(metabolism)
- Natriuretic Peptide, Brain
(metabolism)
- Natriuretic Peptides
(metabolism)
- Obesity
(etiology, metabolism, prevention & control)
- Oxygen Consumption
- PPAR delta
(metabolism)
- PPAR gamma
(metabolism)
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Protein Kinases
(metabolism)
- Receptors, Atrial Natriuretic Factor
(metabolism)
- Trans-Activators
(metabolism)
- Transcription Factors
- Up-Regulation
|