Clinical characteristics of laryngeal cancer in BRCA-1 mutation carriers.

Abstract

BACKGROUND:

The aim of this study was to analyze the occurrence of clinical features characteristic of breast cancer type 1 susceptibility protein (BRCA-1)-dependent tumors in a series of BRCA-1 mutation carriers with laryngeal cancer.

PATIENTS AND METHODS:

The clinical features of five laryngeal cancer patients with BRCA-1 mutations registered in our center were analyzed for: sex, age at diagnosis, age at operation, tumor size and localization, histopathological subtype and grading, lymph node and distant metastases, mode of treatment and long term results of the therapy.

RESULTS:

The five patients were all men, with an average age at diagnosis of 52.4 years. The majority of the patients had clinical features typical of BRCA-1-dependent tumors: four out of the five patients had advanced staging at the time of diagnosis and in three of them the disorder disseminated within one year of follow-up.

CONCLUSION:

Since laryngeal carcinomas in men with BRCA-1 mutations show clinical features characteristic of BRCA-1 dependent tumors, it is reasonable to consider treatment modifications appropriate for this sub-group of tumors.

• Authors: Ewa Jaworowska, Czesława Tarnowska, Jakub Lubiński, Pablo Serrano-Fernández, Tomasz Huzarski, Bogdan Górski, Bartlomiej Masojć, Jerzy Jakubiszyn, Aleksandra Korytowska, Andrzej Kram, Jerzy Rabczynski, Jan Lubiński
• Journal: Anticancer research (Anticancer Res) Vol. 29 Issue 7 Pg. 2703-5 (Jul 2009) ISSN: 1791-7530 [Electronic] Greece
• PMID: 19596949 (Publication Type: Journal Article)

Topics

• Genes, BRCA1
• Genetic Carrier Screening
• Humans
• Laryngeal Neoplasms (genetics, pathology)
• Male
• Middle Aged
• Mutation