Abstract | BACKGROUND: METHODS: In this study, we examined whether PR3-ANCA sera and purified immunoglobulins from patients with Wegener's granulomatosis prime human monocytic cells for enhanced responses to microbial components in terms of production of proinflammatory cytokines. RESULTS: CONCLUSION: In conclusion, PR3-ANCA prime human mononuclear cells to produce cytokines upon stimulation with various microbial components by up-regulating the TLR and NOD signaling pathway, and these mechanisms may partially participate in the inflammatory process in Wegener's granulomatosis.
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Authors | Akiko Uehara, Tadasu Sato, Atsushi Iwashiro, Sou Yokota |
Journal | Diagnostic pathology
(Diagn Pathol)
Vol. 4
Pg. 23
(Jul 14 2009)
ISSN: 1746-1596 [Electronic] England |
PMID | 19594951
(Publication Type: Journal Article)
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