Antiproteinuric effect of angiotensin-converting enzyme inhibitors and an angiotensin II receptor blocker in patients with lupus nephritis.

Abstract

Although the effects of angiotensin II receptor blockers (ARBs) on non-diabetic glomerulonephritis have been reported, studies of their effects on collagen-vascular diseases, particularly lupus nephritis, are limited. In this retrospective, observational study, systemic lupus erythematosus (SLE) patients (n = 7) with lupus nephritis and uncontrolled proteinuria were treated with an angiotensin-converting enzyme inhibitor followed by the ARB losartan (25 - 50 mg/day). Urinary protein excretion and renal function were evaluated. After 12 months of losartan, mean urinary protein excretion decreased significantly by 84.8%. Mean systolic and diastolic blood pressures also decreased significantly during the 12 months of losartan treatment, although not in normotensive patients. Complement 4, total complement activity and anti-dsDNA antibody levels, which are indices of SLE activity, and serum creatinine levels, which is an index of renal function, showed no change in response to losartan treatment. A more extensive evaluation of the effects of ARBs in patients with lupus nephritis and poorly controlled proteinuria is required.

• Authors: N Kitamura, Y Matsukawa, M Takei, S Sawada
• Journal: The Journal of international medical research (J Int Med Res) 2009 May-Jun Vol. 37 Issue 3 Pg. 892-8 ISSN: 0300-0605 [Print] England
• PMID: 19589275 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Angiotensin II Type 1 Receptor Blockers
• Angiotensin-Converting Enzyme Inhibitors
• Antibodies, Antinuclear
• Complement System Proteins
• Creatinine
• Losartan

Topics

• Adolescent
• Adult
• Angiotensin II Type 1 Receptor Blockers (pharmacology, therapeutic use)
• Angiotensin-Converting Enzyme Inhibitors (pharmacology, therapeutic use)
• Animals
• Antibodies, Antinuclear (metabolism)
• Blood Pressure (drug effects)
• Complement System Proteins (immunology)
• Creatinine (blood)
• Female
• Humans
• Losartan (pharmacology, therapeutic use)
• Lupus Nephritis (blood, drug therapy, immunology)
• Middle Aged
• Proteinuria (drug therapy)