Abstract | CONTEXT: OBJECTIVE: The objective was to analyze a large number of patients with MPO- ANCA-associated vasculitis to determine the time of onset, the drug and dose taken, the clinical symptoms, the relationship between the clinical symptoms and the MPO- ANCA titer, and the incidence. DESIGN: RESULTS: Of the 92 patients, 41 (44.6%) had single-organ failure, 32 (34.8%) had two-organ failure, 13 (14.1%), had three-organ failure, and two (2.2%) had four-organ failure. The number of organs involved was unknown in the other four patients (4.3%). The median time of onset was 42 months (range, 1-372 months) after starting drug treatment. The median dose at onset of MPO- ANCA-associated vasculitis was 15 mg/d (range, 2.5-45 mg/d) for methimazole and 200 mg/d (50-450 mg/d) for propylthiouracil. The severity and number of organs involved were not correlated with the MPO- ANCA titer. The incidence was between 0.53 and 0.79 patients per 10,000, and the ratio of the estimated incidences for methimazole and propylthiouracil was 1:39.2. CONCLUSIONS: The time of onset of MPO- ANCA-associated vasculitis and the dose at onset varied. The severity and number of organs involved were not correlated with the MPO- ANCA titer, indicating a need for vigilance even when the MPO- ANCA titer is only weakly positive.
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Authors | Jaeduk Yoshimura Noh, Shigemitu Yasuda, Shotaro Sato, Masako Matsumoto, Yo Kunii, Yoshihiko Noguchi, Koji Mukasa, Kunihiko Ito, Koichi Ito, Osamu Sugiyama, Hiroshi Kobayashi, Shigeru Nihojima, Masaru Okazaki, Shunji Yokoyama |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 94
Issue 8
Pg. 2806-11
(Aug 2009)
ISSN: 1945-7197 [Electronic] United States |
PMID | 19491223
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
- Antithyroid Agents
- Peroxidase
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Antineutrophil Cytoplasmic
(blood, physiology)
- Antithyroid Agents
(adverse effects)
- Child
- Female
- Humans
- Male
- Middle Aged
- Peroxidase
(immunology)
- Vasculitis
(etiology)
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