[The fibrinolytic system in the hypercoagulation syndrome in patients with pulmonary tuberculosis].

Abstract

One hundred and twenty-four patients with different forms of active pulmonary tuberculosis were examined. The fibrinolytic system was assessed from the time of plasma fibrin clot lysis, plasminogen (PG) concentrations, and alpha2-antiplasmin (alpha2-AP) activity. The findings were compared with the recordings of a coagulogram, the concentration ofintravascular coagulation (IVC) markers--soluble fibrinmonomer complexes (SFMC) and D-dimers (DD), as well as with systemic inflammation indices (C-reactive protein and haptoglobin). The patients with pulmonary tuberculosis were found to have a hypercoagulation shift in the hemostatic system, which was accompanied by IVC events and quantitatively associated with the degree of systemic inflammation. This was followed by the moderately elevated PG concentrations in a third of patients and enhanced alpha2-AP activity in two thirds. The prevailing alpha2-AP rise resulted in delayed forming fibrin lysis. When influenced by a number of competitive factors, the values of PG and alpha2-AP directly correlated only with fibrinogen levels (directly). The concentration of DD directly correlated with the markers of systemic inflammation and SFMC, showed no correlations with the indices of the fibrinolytic and hemostatic systems. No correlations between PG, alpha2-AP, and DD suggests that in addition to secretion of corresponding factors, processes of their uptake play a large role in the formation of the functional status of the fibrinolytic system.

• Authors: G O Kaminskaia, E V Martynova, B A Serebrianaia, O G Komissarova
• Journal: Problemy tuberkuleza i boleznei legkikh (Probl Tuberk Bolezn Legk) Issue 3 Pg. 51-4 ( 2009) ISSN: 1728-2993 [Print] Russia (Federation)
• PMID: 19455989 (Publication Type: Comparative Study, Evaluation Study, Journal Article)

Chemical References

• alpha 1-Antitrypsin
• Fibrin
• Fibrinogen
• Plasminogen
• C-Reactive Protein

Topics

• Adolescent
• Adult
• Aged
• Blood Coagulation Tests
• C-Reactive Protein (analysis)
• Female
• Fibrin (analysis)
• Fibrinogen (analysis)
• Fibrinolysis
• Humans
• Male
• Middle Aged
• Plasminogen (analysis)
• Tuberculosis, Pulmonary (blood)
• alpha 1-Antitrypsin (blood)