Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection.

Abstract

Low-density lipoprotein receptor (LDLR) is involved in the entry of hepatitis C virus (HCV) in host cells. We investigated whether three single-nucleotide alterations within LDLR might be associated with the course of hepatitis C infection and response to antiviral therapy. We enrolled 651 individuals with chronic HCV infection who had received interferon-based combination therapy, 174 individuals with self-limited HCV infection, and 516 healthy controls. LDLR c.1171G>A, c.1413G>A, and c.*52G>A genotyping was performed by real-time PCR-based assays. HCV genotype 1-infected individuals who were homozygous for 3'UTR c.*52G were at increased risk for virologic non-response to antiviral therapy compared to virologic responders (66.3% vs. 51.0%, p=0.001). Furthermore, compared to healthy controls, self-limited HCV genotype 1 infection was significantly associated with c.1171A (15.1% vs. 6.6%, p=0.006) and negatively associated with c.1413G>A heterozygosity (33.0% vs. 46.1%, p=0.023). The data indicate that LDLR alterations are correlated with response to interferon-based combination therapy and with self-limitation of HCV 1 infection.

• Authors: Andreas Mas Marques, Tobias Mueller, Justus Welke, Stefan Taube, Christoph Sarrazin, Manfred Wiese, Juliane Halangk, Heiko Witt, Golo Ahlenstiel, Ulrich Spengler, Uwe Goebel, Eckart Schott, Viola Weich, Beate Schlosser, Hermann E Wasmuth, Frank Lammert, Thomas Berg, Eckart Schreier
• Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (Infect Genet Evol) Vol. 9 Issue 5 Pg. 847-52 (Sep 2009) ISSN: 1567-7257 [Electronic] Netherlands
• PMID: 19446659 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 3' Untranslated Regions
• Antiviral Agents
• Receptors, LDL
• Interferons

Topics

• 3' Untranslated Regions
• Adult
• Aged
• Antiviral Agents (therapeutic use)
• Case-Control Studies
• Cross-Sectional Studies
• Exons
• Female
• Genotype
• Hepatitis C, Chronic (drug therapy, genetics)
• Humans
• Interferons (therapeutic use)
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• Polymorphism, Single Nucleotide
• Receptors, LDL (genetics)
• Remission Induction
• Remission, Spontaneous
• Young Adult