Abstract | AIM OF THE STUDY: To investigate the effects of the ethanol extract from Portulaca oleracea (EEPO) on hypoxia models mice and to find the possible mechanism of its anti-hypoxic actions so as to elucidate the anti- hypoxia activity and provide scientific basis for the clinical use of Portulaca oleracea. MATERIALS AND METHODS: RESULTS: Given orally, the EEPO at doses of 100, 200, 400 mg/kg could dose-dependently enhance the survival time of mice in both of the normobaric and chemical hypoxia models. The activity of the glycolysis enzymes and the level of ATP were higher than those of the control. In the pentobarbital sodium-induced sleeping time test and the open-field test, EEPO neither significantly enhanced the pentobarbital sodium-induced sleeping time nor impaired the motor performance, indicating that the observed anti-hypoxic activity was unlikely due to sedation or motor abnormality. CONCLUSIONS: These results demonstrated that the EEPO possessed notable anti-hypoxic activity, which might be related to promoting the activity of the key enzymes in glycolysis and improving the level of ATP in hypoxic mice.
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Authors | Cheng-Jie Chen, Wan-Yin Wang, Xiao-Li Wang, Li-Wei Dong, Yi-Tian Yue, Hai-Liang Xin, Chang-Quan Ling, Min Li |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 124
Issue 2
Pg. 246-50
(Jul 15 2009)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 19397978
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Plant Extracts
- Adenosine Triphosphate
- L-Lactate Dehydrogenase
- Phosphofructokinases
- Pyruvate Kinase
- Sodium Nitrite
- Potassium Cyanide
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Topics |
- Adenosine Triphosphate
(metabolism)
- Animals
- Brain
(drug effects, enzymology, metabolism)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Glycolysis
(drug effects)
- Hypoxia
(chemically induced, metabolism, prevention & control)
- L-Lactate Dehydrogenase
(metabolism)
- Mice
- Mice, Inbred ICR
- Panax
- Phosphofructokinases
(metabolism)
- Phytotherapy
- Plant Components, Aerial
- Plant Extracts
(pharmacology, therapeutic use)
- Portulaca
- Potassium Cyanide
- Pyruvate Kinase
(metabolism)
- Sleep
(drug effects)
- Sodium Nitrite
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