Phosphofructokinases

Allosteric enzymes that regulate glycolysis and gluconeogenesis. These enzymes catalyze phosphorylation of fructose-6-phosphate to either fructose-1,6-bisphosphate (PHOSPHOFRUCTOKINASE-1 reaction), or to fructose-2,6-bisphosphate (PHOSPHOFRUCTOKINASE-2 reaction).

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Networked: 536 relevant articles (11 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sola-Penna, Mauro: 4 articles (01/2017 - 08/2003)
2.	Joanisse, Denis R: 4 articles (01/2010 - 03/2002)
3.	Lu, Yunfei: 3 articles (01/2016 - 04/2009)
4.	Zhang, Xiaodong: 3 articles (01/2016 - 04/2009)
5.	Dumitrescu, Alexandra M: 3 articles (01/2006 - 02/2005)
6.	Moeller, Lars C: 3 articles (01/2006 - 02/2005)
7.	Refetoff, Samuel: 3 articles (01/2006 - 02/2005)
8.	Petty, Howard R: 2 articles (01/2022 - 10/2021)
9.	Wang, Qian: 2 articles (01/2022 - 04/2005)
10.	Li, Ling: 2 articles (12/2021 - 01/2021)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/2013 - "In this study, we analyzed the expression of 15 phosphofructokinase-encoding genes in roots and aerial tissues of anoxia-tolerant rice seedlings in response to anoxic stress and compared our data with transcript profiles obtained from microarray analyses. " 01/01/2020 - "Curiously, phosphofructokinase (PFK) activity was significantly down-regulated within 4 h during hypoxia, although these effects were transient, and most indices returned to control levels after 12 h of re-oxygenation. " 11/01/2013 - "SIT in hypoxia up-regulated muscle phosphofructokinase activity and the anaerobic threshold more than SIT in normoxia but did not enhance endurance exercise performance." 01/01/2013 - "Characterization of the phosphofructokinase gene family in rice and its expression under oxygen deficiency stress." 07/27/2001 - "Within 1 min after initiating hypoxia, glycolysis was activated through activation of phosphofructokinase. "
2.	Glycogen Storage Disease Type V (McArdle's Disease) 09/01/2005 - "Clinically, PGAMD resembles muscle phosphorylase deficiency (McArdle disease) and phosphofructokinase deficiency (PFKD). " 06/01/2004 - "We studied five patients with McArdle's disease, one patient with phosphofructokinase deficiency and six normal subjects. " 07/01/1991 - "Myophosphorylase deficiency responds to intravenous glucose administration with improved exercise bioenergetics, but no such response is seen in phosphofructokinase deficiency. " 01/01/2014 - "We measured muscle glycogen levels in vivo in the calf muscle in three patients with McArdle disease (MD), one patient with phosphofructokinase deficiency (PFKD) and four healthy controls by performing 13C MRS at 7T. " 12/01/1980 - "A model of the human neuromuscular disorders myophosphorylase deficiency and phosphofructokinase deficiency has been developed using intra-aortic injection of sodium iodoacetate in adult male rats. "
3.	Glycogen Storage Disease (Glycogenosis) 10/01/2007 - "Studies on phosphofructokinase deficiency vastly enriched the field of glycogen storage diseases, making a relevant improvement also in the molecular genetic area. " 01/01/1984 - "The kinetic properties of phosphofructokinases (PFKs) from normal human liver, muscle and erythrocytes, and from erythrocytes of two unrelated patients with type VII glycogenosis (muscle PFK deficiency, McKusick 23280) were analysed in this study. " 01/01/2004 - "(31)P-magnetic resonance spectroscopy provided characteristic spectra of type VII glycogen storage disease (phosphofructokinase deficiency)." 01/01/1996 - "Novel missense mutation (W686C) of the phosphofructokinase-M gene in a Japanese patient with a mild form of glycogenosis VII." 04/01/1992 - "Fatal familial infantile glycogen storage disease: multisystem phosphofructokinase deficiency."
4.	Muscular Diseases (Myopathy) 06/01/2001 - "Phosphofructokinase (PFK) deficiency is an autosomal recessive inherited disorder in dogs causing haemolytic crises and exertional myopathy. " 01/01/1996 - "Partial block of glycolysis in late-onset phosphofructokinase deficiency myopathy." 01/01/1990 - "A severe, progressive myopathy developed in an 11-year-old, phosphofructokinase (PFK)-deficient, male, English Springer Spaniel dog. " 12/01/1988 - "Metabolic myopathy in canine muscle-type phosphofructokinase deficiency." 11/01/1983 - "Phosphofructokinase deficiency associated with congenital nonspherocytic hemolytic anemia and mild myopathy: biochemical and morphological studies on the muscle."
5.	Ischemia 10/01/1994 - "In both warm and cold ischemic livers, levels of fructose-6-phosphate (F6P) and fructose-1,6-bisphosphate (F1,6P2) indicated a marked activation of glycolysis at the phosphofructokinase (PFK) locus after a certain time of ischemia. " 01/01/1982 - "4. Phosphofructokinase activity was inhibited by methohexital in the recovery period after ischemia or anoxia, respectively. " 11/01/1998 - "LAD/LADc ratios were increased for hexokinase (1.69), phosphofructokinase (3.69), and glyceraldehyde-3-phosphate dehydrogenase (2.29) in the ischemia heart and for phosphofructokinase (3.90), glyceraldehyde-3-phosphate dehydrogenase (2.20), GLUT 4 (1.55) and GLUT 1 (2.20) in the ischemia/reflow heart. " 01/01/1988 - "We evaluated the anti-ischemic effect of drugs by using the inhibition of glycolytic flux at the level of the phosphofructokinase (PFK) reaction, caused by ischemia, as an indicator of the oxygen supply/demand ratio in the ischemic myocardium. " 09/01/1982 - "It appears that inhibition of myocardial phosphofructokinase activity during ischemia is partly due to an increase in the levels of citrate and hydrogen ions in the ischemic tissue."

Related Drugs and Biologics

1.	Enzymes
2.	Glucose (Dextrose)
3.	Pyruvate Kinase
4.	Citric Acid (Citrate)
5.	Messenger RNA (mRNA)
6.	Hexokinase
7.	Facilitative Glucose Transport Proteins (Glucose Transporter)
8.	Adenosine Triphosphate (ATP)
9.	Glycogen
10.	Glucose-6-Phosphate Isomerase (Phosphoglucose Isomerase)

Related Therapies and Procedures

1.	Ketogenic Diet
2.	Mastectomy (Mammectomy)
3.	Hypophysectomy