Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models.

Abstract

Progesterone receptors (PR), members of the nuclear receptor superfamily, function as ligand-activated transcription factors and initiators of c-Src kinase and mitogen-activated protein kinase signaling. Bidirectional cross-talk between PR and mitogenic protein kinases results in changes in PR post-translational modification, leading to alterations in PR transcriptional activity and promoter selectivity. PR-induced rapid activation of cytoplasmic protein kinases insures precise regulatory input to downstream cellular processes that are dependent upon nuclear PR, such as cell-cycle progression, and pro-survival signaling. Here, we review interactions between PR and mitogenic protein kinases and discuss the consequences of specific post-translational modifications on PR action in breast cancer cell-line models.

• Authors: Gwen E Dressing, Christy R Hagan, Todd P Knutson, Andrea R Daniel, Carol A Lange
• Journal: Endocrine-related cancer (Endocr Relat Cancer) Vol. 16 Issue 2 Pg. 351-61 (Jun 2009) ISSN: 1351-0088 [Print] England
• PMID: 19357196 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Receptors, Progesterone
• Protein Kinases

Topics

• Breast Neoplasms (metabolism, pathology)
• Female
• Humans
• Protein Kinases (metabolism)
• Protein Processing, Post-Translational
• Receptors, Progesterone (physiology)
• Signal Transduction