Sleep duration as a risk factor for the development of type 2 diabetes or impaired glucose tolerance: analyses of the Quebec Family Study.

Abstract

OBJECTIVE:

To examine the long-term relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT).

METHODS:

Body composition measurements and self-reported sleep duration were determined in a longitudinal sample of 276 individuals aged 21 to 64 years followed for a mean of 6 years. Risk factors of type 2 diabetes/IGT over the follow-up were determined and relative risks (RRs) calculated for the development of type 2 diabetes/IGT by sleep duration group.

RESULTS:

Independent risk factors of type 2 diabetes/IGT over the follow-up included age, obesity, sleep duration, and glucose/insulin homeostasis indicators. Using adults with 7-8h of sleep as a reference, the adjusted RR for the development of type 2 diabetes/IGT was 2.78 (1.61-4.12) for those with 6h of sleep and 2.54 (1.42-3.53) for those with 9h of sleep. These elevated RRs remained significant after adjustment for body mass index, waist circumference or percent body fat.

CONCLUSION:

Short and long sleeping times are associated with a higher risk of developing type 2 diabetes/IGT, independent of several covariates. These results suggest that sleep duration may represent a novel risk factor for type 2 diabetes/IGT.

• Authors: Jean-Philippe Chaput, Jean-Pierre Després, Claude Bouchard, Arne Astrup, Angelo Tremblay
• Journal: Sleep medicine (Sleep Med) Vol. 10 Issue 8 Pg. 919-24 (Sep 2009) ISSN: 1878-5506 [Electronic] Netherlands
• PMID: 19332380 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Insulin

Topics

• Adult
• Blood Glucose (metabolism)
• Diabetes Mellitus, Type 2 (epidemiology, metabolism)
• Family Health
• Female
• Follow-Up Studies
• Glucose Intolerance (epidemiology, metabolism)
• Homeostasis (physiology)
• Humans
• Insulin (blood)
• Male
• Middle Aged
• Quebec (epidemiology)
• Risk Factors
• Sleep
• Sleep Wake Disorders (epidemiology, metabolism)
• Young Adult