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Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease.

Abstract
Interleukin-18 (IL-18)-656T/G, -607A/C, and -137C/G promoter polymorphisms had been reported associated with Kawasaki disease (KD). An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma, rheumatoid, and systemic lupus erythematosus. We tested a hypothesis that the IL-18 105A/C genetic polymorphism confers KD susceptibility. Study participants were Taiwanese KD patients and a healthy control group. Our data indicated that the frequency of C allele was significantly higher in the patient group (13.9%) than in the control group (2.7%; P<0.0001, odds ratio [OR]=5.93; 95% confidence interval [CI]=2.57-13.73). Therefore, persons with the C allele may have higher risk of developing KD. In addition, compared with the haplotype frequencies between case and control groups, the KD patients with TACC haplotype appeared to be a significant "at-risk" haplotype compared with other haplotypes (OR: 4.62, 95% CI: 1.71-12.43; P=0.001). KD patient with the TAGA haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.51, 95% CI:0.29-0.89; P=0.017). Our results suggest that 105A/C polymorphism and the haplotypes in IL-18 gene are associated with the risk of KD in Taiwanese population.
AuthorsShih-Yin Chen, Lei Wan, Yu-Chuen Huang, Jim Jinn-Chyuan Sheu, Yu-Ching Lan, Chih-Ho Lai, Cheng-Wen Lin, Jeng Sheng Chang, Yuhsin Tsai, Shih-Ping Liu, Ying-Ju Lin, Fuu-Jen Tsai
JournalJournal of clinical laboratory analysis (J Clin Lab Anal) Vol. 23 Issue 2 Pg. 71-6 ( 2009) ISSN: 1098-2825 [Electronic] United States
PMID19288449 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright(c) 2009 Wiley-Liss, Inc.
Chemical References
  • Interleukin-18
Topics
  • Chi-Square Distribution
  • Child
  • Child, Preschool
  • Coronary Vessels (pathology)
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease (epidemiology)
  • Haplotypes
  • Humans
  • Infant
  • Interleukin-18 (genetics)
  • Logistic Models
  • Male
  • Mucocutaneous Lymph Node Syndrome (epidemiology, genetics)
  • Polymorphism, Single Nucleotide
  • Taiwan (epidemiology)

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