Abstract |
Interleukin-18 (IL-18)-656T/G, -607A/C, and -137C/G promoter polymorphisms had been reported associated with Kawasaki disease (KD). An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma, rheumatoid, and systemic lupus erythematosus. We tested a hypothesis that the IL-18 105A/C genetic polymorphism confers KD susceptibility. Study participants were Taiwanese KD patients and a healthy control group. Our data indicated that the frequency of C allele was significantly higher in the patient group (13.9%) than in the control group (2.7%; P<0.0001, odds ratio [OR]=5.93; 95% confidence interval [CI]=2.57-13.73). Therefore, persons with the C allele may have higher risk of developing KD. In addition, compared with the haplotype frequencies between case and control groups, the KD patients with TACC haplotype appeared to be a significant "at-risk" haplotype compared with other haplotypes (OR: 4.62, 95% CI: 1.71-12.43; P=0.001). KD patient with the TAGA haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.51, 95% CI:0.29-0.89; P=0.017). Our results suggest that 105A/C polymorphism and the haplotypes in IL-18 gene are associated with the risk of KD in Taiwanese population.
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Authors | Shih-Yin Chen, Lei Wan, Yu-Chuen Huang, Jim Jinn-Chyuan Sheu, Yu-Ching Lan, Chih-Ho Lai, Cheng-Wen Lin, Jeng Sheng Chang, Yuhsin Tsai, Shih-Ping Liu, Ying-Ju Lin, Fuu-Jen Tsai |
Journal | Journal of clinical laboratory analysis
(J Clin Lab Anal)
Vol. 23
Issue 2
Pg. 71-6
( 2009)
ISSN: 1098-2825 [Electronic] United States |
PMID | 19288449
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2009 Wiley-Liss, Inc. |
Chemical References |
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Topics |
- Chi-Square Distribution
- Child
- Child, Preschool
- Coronary Vessels
(pathology)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
(epidemiology)
- Haplotypes
- Humans
- Infant
- Interleukin-18
(genetics)
- Logistic Models
- Male
- Mucocutaneous Lymph Node Syndrome
(epidemiology, genetics)
- Polymorphism, Single Nucleotide
- Taiwan
(epidemiology)
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