Abstract | OBJECTIVE: METHODS: Male Sprague-Dawley rats underwent unilateral nephrectomy and received subcutaneous DOCA pellets as well as 1% NaCl for drinking. Simultaneously, rats were treated with 5 mg/kg per day fluvastatin, or solvent only for 6 weeks. Mean arterial pressure was measured intraarterially. Glomerulosclerosis, interstitial fibrosis, cell proliferation, inflammation and podocyte damage were evaluated on kidney sections. Inflammatory markers were measured by real-time PCR. RESULTS: CONCLUSION:
Statin treatment reduces mortality and glomerular damage independent from blood pressure in a low- renin model of hypertensive nephrosclerosis. A reduction of podocyte damage and macrophage infiltration may explain the beneficial effects of fluvastatin.
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Authors | Andrea Hartner, Bernd Klanke, Nada Cordasic, Kerstin Amann, Roland E Schmieder, Roland Veelken, Karl F Hilgers |
Journal | Journal of hypertension
(J Hypertens)
Vol. 27
Issue 2
Pg. 376-85
(Feb 2009)
ISSN: 0263-6352 [Print] England |
PMID | 19226708
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fatty Acids, Monounsaturated
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Indoles
- Desoxycorticosterone
- Fluvastatin
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Topics |
- Animals
- Blood Pressure
- Cell Proliferation
- Desoxycorticosterone
- Disease Progression
- Fatty Acids, Monounsaturated
(pharmacology, therapeutic use)
- Fluvastatin
- Glomerulonephritis
(etiology, prevention & control)
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(pharmacology, therapeutic use)
- Hypertension
(drug therapy, etiology, metabolism, pathology)
- Indoles
(pharmacology, therapeutic use)
- Kidney
(pathology)
- Male
- Nephrosclerosis
(etiology, prevention & control)
- Organ Size
- Podocytes
(drug effects, pathology)
- Rats
- Rats, Sprague-Dawley
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