Abstract | BACKGROUND: METHODS: We assessed the associations for use of aspirin, other NSAIDs, and acetaminophen with breast cancer risk among premenopausal women in the prospective Nurses' Health Study II. In total, 112,292 women, aged 25 to 42 years and free of cancer in 1989, were followed up until June 2003. Multivariate relative risks and 95% confidence intervals were calculated by Cox proportional hazards models, adjusting for age and other important breast cancer risk factors. RESULTS: Overall, 1345 cases of invasive premenopausal breast cancer were documented. Regular use of aspirin (> or = 2 times per week) was not significantly associated with breast cancer risk (relative risk, 1.07; 95% confidence interval, 0.89-1.29). Regular use of either nonaspirin NSAIDs or acetaminophen also was not consistently associated with breast cancer risk. Results did not vary by frequency (days per week), dose ( tablets per week), or duration of use. Furthermore, associations with each drug category did not vary substantially by estrogen and progesterone receptor status of the tumor. CONCLUSION:
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Authors | A Heather Eliassen, Wendy Y Chen, Donna Spiegelman, Walter C Willett, David J Hunter, Susan E Hankinson |
Journal | Archives of internal medicine
(Arch Intern Med)
Vol. 169
Issue 2
Pg. 115-21; discussion 121
(Jan 26 2009)
ISSN: 1538-3679 [Electronic] United States |
PMID | 19171806
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Acetaminophen
- Aspirin
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Topics |
- Acetaminophen
(administration & dosage, adverse effects)
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, adverse effects)
- Aspirin
(administration & dosage, adverse effects)
- Breast Neoplasms
(chemically induced)
- Female
- Humans
- Premenopause
- Risk Factors
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