Abstract |
The 12/ 15-lipoxygenase plays a janus-role in inflammation with pro-inflammatory and anti-inflammatory effects in cell systems and even opposite effects on atherosclerosis in two different animal species. Screening of the human 15-lipoxygenase (ALOX15) gene detected a polymorphic C to T substitution at position c.-292, which led to three times higher ALOX15 activity in macrophages and showed a trend to be atheroprotective in a small case-control study for coronary artery disease (CAD). A second polymorphism at position c.1693C>T leading to an T560M exchange and an inactive enzyme was recently associated with increased CAD. We now investigated whether these polymorphisms or a certain haplotype of ALOX15 are associated with myocardial infarction (MI) in a case-control subset from the population-based MONIKA/KORA cohort S3. Six polymorphisms in ALOX15 were analyzed in 2629 participants to cover all major haplotypes with a frequency higher than 1% in the Caucasian population. None of the polymorphism was associated with MI but a rare ALOX15 haplotype showed a significant protective effect on the risk for MI (p=0.03). However, none of the polymorphisms or haplotypes was associated with CRP levels. These data suggest that ALOX15 may play a less prominent role during later stages of atherosclerosis involving atherothrombotic mechanisms than eventually during early plaque development.
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Authors | Martin Hersberger, Martina Müller, Jacqueline Marti-Jaun, Iris M Heid, Stefan Coassin, Thomas F Young, Vanessa Waechter, Christian Hengstenberg, Christine Meisinger, Annette Peters, Wolfgang König, Stephan Holmer, Heribert Schunkert, Norman Klopp, Florian Kronenberg, Thomas Illig |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 205
Issue 1
Pg. 192-6
(Jul 2009)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 19131063
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- C-Reactive Protein
- ALOX15 protein, human
- Arachidonate 15-Lipoxygenase
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Topics |
- Arachidonate 15-Lipoxygenase
(genetics, physiology)
- C-Reactive Protein
(metabolism)
- Case-Control Studies
- Cohort Studies
- Female
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Inflammation
- Macrophages
(metabolism)
- Male
- Middle Aged
- Myocardial Infarction
(genetics)
- Polymorphism, Genetic
- Thrombosis
(metabolism)
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