Abstract | OBJECTIVE: The objective of the study was to assess the efficacy of maternal betamethasone for improving preterm lung function in the presence of inflammation induced by amniotic fluid Ureaplasma colonization. STUDY DESIGN: Ewes bearing single fetuses were randomized to receive an intraamniotic injection of Ureaplasma parvum (serovar 6; 2 x 10(7) colony-forming units) or vehicle at 86 +/- 2 days of pregnancy (mean +/- SD: term is 150 days), followed by maternal intramuscular betamethasone (0.5 mg/kg) or saline, either 2 or 7 days before delivery of lambs at 123 +/- 1 d. RESULTS: CONCLUSION:
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Authors | Timothy J M Moss, Ilias Nitsos, Christine L Knox, Graeme R Polglase, Suhas G Kallapur, Machiko Ikegami, Alan H Jobe, John P Newnham |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 200
Issue 1
Pg. 96.e1-6
(Jan 2009)
ISSN: 1097-6868 [Electronic] United States |
PMID | 19121661
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Glucocorticoids
- Pulmonary Surfactants
- Betamethasone
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Topics |
- Amniotic Fluid
(metabolism, microbiology)
- Animals
- Animals, Newborn
- Betamethasone
(pharmacology)
- Bronchoalveolar Lavage Fluid
- Cytokines
(chemistry, genetics)
- Endometritis
(complications, metabolism, microbiology)
- Female
- Glucocorticoids
(pharmacology)
- Lung
(drug effects, embryology)
- Male
- Pregnancy
- Pregnancy Complications, Infectious
(metabolism, microbiology)
- Pulmonary Surfactants
(metabolism)
- Random Allocation
- Reverse Transcriptase Polymerase Chain Reaction
- Sheep
- Ureaplasma
(growth & development)
- Ureaplasma Infections
(complications, metabolism, microbiology)
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