Abstract |
In 20 patients with oesophageal carcinoma blood samples were taken after the first irradiation and the activity of the glycolytic enzyme glucose-6-phosphate isomerase was measured. In all patients there occur GPI peaks at reproducible times. The height of the enzyme peak occurring 15.5 to 19.5 hours p. irr. expresses a significant dependence on tumour size and irradiation dose. The frequency of a late occurring enzyme peak depends on the appearance of regional lymph node metastases. Possible sources of the enzyme peaks are discussed from a radiobiological point of view and the meaning of such enzyme peaks for the optimization of radiation therapy is pointed out.
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Authors | D Tunak, M Below, K H Dallüge, P Henkel, T Nicolai, F Kuchenbecker |
Journal | Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR
(Gastroenterol J)
Vol. 51
Issue 1
Pg. 22-6
( 1991)
ISSN: 0863-1743 [Print] Germany |
Vernacular Title | Möglichkeiten der Optimierung der Strahlentherapie von Oesophaguskarzinomen durch die Messung des onkoradiogenen Enzympeaks der GPI. |
PMID | 1910491
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Glucose-6-Phosphate Isomerase
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Topics |
- Adult
- Aged
- Carcinoma, Squamous Cell
(enzymology, radiotherapy)
- Esophageal Neoplasms
(enzymology, radiotherapy)
- Female
- Glucose-6-Phosphate Isomerase
(blood)
- Humans
- Lymphatic Metastasis
- Male
- Middle Aged
- Patient Care Planning
- Plasma Volume
- Radiotherapy Dosage
- Time Factors
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