Contributions of biological tumor parameters to the incorporation rate of L: -[methyl-(11)C] methionine into astrocytomas and oligodendrogliomas.

Abstract

We compared the tumor uptake of (11)C-methionine (MET) with positron emission tomography (PET) with the results of a pathological analysis to examine the proliferative potential and microvessel density measured with immunostaining for MIB-1 and factor VIII, respectively, from 33 patients with glioma. The MET uptake in oligodendrogliomas was significantly greater than that in grade 2 astrocytomas and comparable to those in grade 3 and 4 astrocytomas. The MIB-1 index of oligodendroglioma meanwhile was comparable to that of grade 2 astrocytoma. The microvessel area in oligodendroglioma was significantly greater than that in grade 2 astrocytomas and comparable to those in grade 3 and 4 astrocytomas. According to a multivariate statistical analysis, MET uptake ratio was closely correlated with the MIB-1 index among astrocytomas. An increase in the microvessel area in the oligodendrogliomas contributed to the higher MET uptake among the tumors with a low-proliferative index. This information is important for interpreting the results of MET-PET studies for clinical use.

• Authors: Takeko Nojiri, Tadashi Nariai, Masaru Aoyagi, Michio Senda, Kenji Ishii, Kiichi Ishiwata, Kikuo Ohno
• Journal: Journal of neuro-oncology (J Neurooncol) Vol. 93 Issue 2 Pg. 233-41 (Jun 2009) ISSN: 1573-7373 [Electronic] United States
• PMID: 19099197 (Publication Type: Journal Article)

Chemical References

• Carbon Radioisotopes
• Factor VIII
• Methionine

Topics

• Adult
• Astrocytoma (blood supply, diagnostic imaging, metabolism, pathology, surgery)
• Capillaries (metabolism, pathology)
• Carbon Radioisotopes
• Cell Division
• Factor VIII (metabolism)
• Female
• Humans
• Male
• Methionine (metabolism)
• Microcirculation
• Middle Aged
• Neoplasm Staging
• Oligodendroglioma (blood supply, diagnostic imaging, metabolism, pathology, surgery)
• Positron-Emission Tomography