Plasma visfatin concentrations after a lifestyle intervention were directly associated with inflammatory markers.

Abstract

BACKGROUND AND AIMS:

The biological activity and regulation of the novel adipokine visfatin are still largely unknown. Our aim was to evaluate if visfatin plasma concentrations may be influenced by a lifestyle intervention.

METHODS AND RESULTS:

Out of 335 dysmetabolic patients from a population-based cohort, randomized to receive a lifestyle intervention program (intervention group) or family physician usual care (controls), 20 patients per group were randomly selected for plasma visfatin determination. The before-after variation (Delta) in visfatin concentration at 1-year from randomization, and the correlations between (Delta)visfatin and intervention-induced changes in waist circumference, fasting glucose, markers of inflammation, and oxidative stress were evaluated. The intervention group showed a significant improvement in waist circumference, and many metabolic/inflammatory variables, while the controls worsened. Visfatin concentrations slightly decreased in the former and significantly increased in the controls ((Delta)visfatin=-2.4 vs 66.0 ng/ml, p<0.001). In robust regression models, the following variables resulted associated with (Delta)visfatin: (Delta)waist circumference, (Delta)fasting glucose, (Delta)hs-CRP (high-sensitivity C-reactive protein) and (Delta)TNFalpha (tumor necrosis factor-alpha). Significant effects on (Delta)visfatin of (Delta)TNFalpha (beta=16.8; 6.1-25.6; p=0.003) and, modified by group, of (Delta)hs-CRP (beta=29.8; 95% CI 15.4-44.2; p<0.001 and beta=4.2; 2.9-5.5; p<0.001 in the control and intervention group, respectively) were detected. By controlling for (Delta)waist, the effects of (Delta)TNFalpha and of (Delta)hs-CRP on (Delta)visfatin by group did not change, while (Delta)waist was no longer associated. The association between (Delta)visfatin and (Delta)glucose was no longer significant, after adjusting for (Delta)hs-CRP.

CONCLUSION:

Visfatin values increased with waist circumference and were associated with variations of inflammatory markers, suggesting participation in inflammatory mechanisms.

• Authors: S Bo, G Ciccone, I Baldi, R Gambino, C Mandrile, M Durazzo, L Gentile, M Cassader, P Cavallo-Perin, G Pagano
• Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD (Nutr Metab Cardiovasc Dis) Vol. 19 Issue 6 Pg. 423-30 (Jul 2009) ISSN: 1590-3729 [Electronic] Netherlands
• PMID: 19073361 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Blood Glucose
• Cytokines
• Inflammation Mediators
• Tumor Necrosis Factor-alpha
• C-Reactive Protein
• Nicotinamide Phosphoribosyltransferase
• nicotinamide phosphoribosyltransferase, human

Topics

• Biomarkers (blood)
• Blood Glucose (metabolism)
• C-Reactive Protein (metabolism)
• Cytokines (blood)
• Diet
• Exercise
• Fasting (blood)
• Female
• Humans
• Inflammation Mediators (blood)
• Male
• Metabolic Syndrome (blood, physiopathology, therapy)
• Middle Aged
• Nicotinamide Phosphoribosyltransferase (blood)
• Oxidative Stress
• Risk Reduction Behavior
• Treatment Outcome
• Tumor Necrosis Factor-alpha (blood)
• Waist Circumference